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本文引用的文献

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Outbreak of OXA-48-positive carbapenem-resistant Klebsiella pneumoniae isolates in France.法国产 OXA-48 阳性碳青霉烯类耐药肺炎克雷伯菌的爆发。
Antimicrob Agents Chemother. 2011 May;55(5):2420-3. doi: 10.1128/AAC.01452-10. Epub 2011 Feb 22.
2
Class D OXA-48 carbapenemase in multidrug-resistant enterobacteria, Senegal.塞内加尔多重耐药肠杆菌中的D类OXA-48碳青霉烯酶
Emerg Infect Dis. 2011 Jan;17(1):143-4. doi: 10.3201/eid1701.100244.
3
Plasmid-encoded OXA-48 carbapenemase in Escherichia coli from Israel.以色列大肠杆菌中质粒编码的OXA-48碳青霉烯酶
J Antimicrob Chemother. 2011 Mar;66(3):672-3. doi: 10.1093/jac/dkq467. Epub 2010 Dec 21.
4
Genetic factors associated with elevated carbapenem resistance in KPC-producing Klebsiella pneumoniae.与产 KPC 肺炎克雷伯菌碳青霉烯类耐药升高相关的遗传因素。
Antimicrob Agents Chemother. 2010 Oct;54(10):4201-7. doi: 10.1128/AAC.00008-10. Epub 2010 Jul 26.
5
First detection of oxacillinase-mediated resistance to carbapenems in Klebsiella pneumoniae from Morocco.首次在摩洛哥肺炎克雷伯菌中检测到由氧青霉烯酶介导的对碳青霉烯类药物的耐药性。
Ann Trop Med Parasitol. 2010 Jun;104(4):327-30. doi: 10.1179/136485910X12743554760108.
6
Emergence of bla KPC-3-Tn4401a associated with a pKPN3/4-like plasmid within ST384 and ST388 Klebsiella pneumoniae clones in Spain.西班牙产 ST384 和 ST388 肺炎克雷伯菌克隆中出现的 bla KPC-3-Tn4401a 与 pKPN3/4 样质粒相关。
J Antimicrob Chemother. 2010 Aug;65(8):1608-14. doi: 10.1093/jac/dkq174. Epub 2010 May 30.
7
Plasmid-mediated carbapenem-hydrolysing OXA-48 beta-lactamase in Klebsiella pneumoniae from Tunisia.突尼斯肺炎克雷伯菌中质粒介导的碳青霉烯水解OXA-48β-内酰胺酶
Int J Antimicrob Agents. 2010 Jul;36(1):91-3. doi: 10.1016/j.ijantimicag.2010.02.014. Epub 2010 Mar 30.
8
Spread of OXA-48-encoding plasmid in Turkey and beyond.OXA-48 编码质粒在土耳其及其他地区的传播。
Antimicrob Agents Chemother. 2010 Mar;54(3):1369-73. doi: 10.1128/AAC.01312-09. Epub 2010 Jan 19.
9
Acquired carbapenemases in Gram-negative bacterial pathogens: detection and surveillance issues.革兰氏阴性细菌病原体中获得性碳青霉烯酶：检测和监测问题。
Clin Microbiol Infect. 2010 Feb;16(2):112-22. doi: 10.1111/j.1469-0691.2009.03116.x.
10
Oxacillinase-mediated resistance to carbapenems in Klebsiella pneumoniae from Lebanon.黎巴嫩肺炎克雷伯菌中由苯唑西林酶介导的对碳青霉烯类抗生素的耐药性
Clin Microbiol Infect. 2008 Sep;14(9):887-8. doi: 10.1111/j.1469-0691.2008.02059.x.

西班牙首次爆发肺炎克雷伯菌中产质粒介导碳青霉烯水解酶 OXA-48。

First outbreak of a plasmid-mediated carbapenem-hydrolyzing OXA-48 beta-lactamase in Klebsiella pneumoniae in Spain.

机构信息

Department of Clinical Microbiology, Hospital Clinic, Villarroel 170, 08036 Barcelona, Spain.

出版信息

Antimicrob Agents Chemother. 2011 Sep;55(9):4398-401. doi: 10.1128/AAC.00329-11. Epub 2011 Jul 11.

DOI:10.1128/AAC.00329-11
PMID:21746954
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC3165339/
Abstract

Twenty Klebsiella pneumoniae isolates producing OXA-48 were collected from April 2009 to September 2010. Strains were clonally related and coproduced a CTX-M-15 β-lactamase. A conjugative plasmid of circa 70 kb carrying bla(OXA-48) was identified. Eleven isolates showed low-level resistance to carbapenems, whereas nine showed high-level resistance. Decreased expression of OmpK36 was related to high-level resistance to carbapenems. The isolates belonged to sequence type 101 (ST101). This is the first outbreak caused by an OXA-48-producing K. pneumoniae strain in Spain.

摘要

2009 年 4 月至 2010 年 9 月期间，共收集了 20 株产 OXA-48 的肺炎克雷伯菌。菌株具有克隆相关性，并共同产生 CTX-M-15 β-内酰胺酶。鉴定出一种约 70kb 的可接合质粒，携带 bla（OXA-48）。11 株对碳青霉烯类药物表现出低水平耐药性，而 9 株则表现出高水平耐药性。OmpK36 的表达减少与碳青霉烯类药物的高水平耐药性有关。这些分离株属于序列型 101（ST101）。这是西班牙首次由产 OXA-48 的肺炎克雷伯菌引起的暴发。