西班牙首次爆发肺炎克雷伯菌中产质粒介导碳青霉烯水解酶 OXA-48。
First outbreak of a plasmid-mediated carbapenem-hydrolyzing OXA-48 beta-lactamase in Klebsiella pneumoniae in Spain.
机构信息
Department of Clinical Microbiology, Hospital Clinic, Villarroel 170, 08036 Barcelona, Spain.
出版信息
Antimicrob Agents Chemother. 2011 Sep;55(9):4398-401. doi: 10.1128/AAC.00329-11. Epub 2011 Jul 11.
Abstract
Twenty Klebsiella pneumoniae isolates producing OXA-48 were collected from April 2009 to September 2010. Strains were clonally related and coproduced a CTX-M-15 β-lactamase. A conjugative plasmid of circa 70 kb carrying bla(OXA-48) was identified. Eleven isolates showed low-level resistance to carbapenems, whereas nine showed high-level resistance. Decreased expression of OmpK36 was related to high-level resistance to carbapenems. The isolates belonged to sequence type 101 (ST101). This is the first outbreak caused by an OXA-48-producing K. pneumoniae strain in Spain.
摘要
2009 年 4 月至 2010 年 9 月期间，共收集了 20 株产 OXA-48 的肺炎克雷伯菌。菌株具有克隆相关性，并共同产生 CTX-M-15 β-内酰胺酶。鉴定出一种约 70kb 的可接合质粒，携带 bla（OXA-48）。11 株对碳青霉烯类药物表现出低水平耐药性，而 9 株则表现出高水平耐药性。OmpK36 的表达减少与碳青霉烯类药物的高水平耐药性有关。这些分离株属于序列型 101（ST101）。这是西班牙首次由产 OXA-48 的肺炎克雷伯菌引起的暴发。
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