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本文引用的文献

1
Diversity, epidemiology, and genetics of class D beta-lactamases.D 类β-内酰胺酶的多样性、流行病学和遗传学。
Antimicrob Agents Chemother. 2010 Jan;54(1):24-38. doi: 10.1128/AAC.01512-08. Epub 2009 Aug 31.
2
Has the era of untreatable infections arrived?无法治愈的感染时代已经来临了吗?
J Antimicrob Chemother. 2009 Sep;64 Suppl 1:i29-36. doi: 10.1093/jac/dkp255.
3
The real threat of Klebsiella pneumoniae carbapenemase-producing bacteria.产肺炎克雷伯菌碳青霉烯酶细菌的真正威胁。
Lancet Infect Dis. 2009 Apr;9(4):228-36. doi: 10.1016/S1473-3099(09)70054-4.
4
Oxacillinase-mediated resistance to carbapenems in Klebsiella pneumoniae from Lebanon.黎巴嫩肺炎克雷伯菌中由苯唑西林酶介导的对碳青霉烯类抗生素的耐药性
Clin Microbiol Infect. 2008 Sep;14(9):887-8. doi: 10.1111/j.1469-0691.2008.02059.x.
5
Plasmid-encoded carbapenem-hydrolyzing beta-lactamase OXA-48 in an imipenem-susceptible Klebsiella pneumoniae strain from Belgium.来自比利时的一株对亚胺培南敏感的肺炎克雷伯菌中质粒编码的碳青霉烯水解β-内酰胺酶OXA-48
Antimicrob Agents Chemother. 2008 Sep;52(9):3463-4. doi: 10.1128/AAC.00543-08. Epub 2008 Jul 21.
6
Spread of OXA-48-positive carbapenem-resistant Klebsiella pneumoniae isolates in Istanbul, Turkey.土耳其伊斯坦布尔OXA-48阳性耐碳青霉烯肺炎克雷伯菌分离株的传播情况
Antimicrob Agents Chemother. 2008 Aug;52(8):2950-4. doi: 10.1128/AAC.01672-07. Epub 2008 Jun 2.
7
Carbapenem-resistant Escherichia coli and Klebsiella pneumoniae isolates from Turkey with OXA-48-like carbapenemases and outer membrane protein loss.来自土耳其的产OXA-48样碳青霉烯酶且外膜蛋白缺失的耐碳青霉烯类大肠杆菌和肺炎克雷伯菌分离株
Int J Antimicrob Agents. 2008 Jun;31(6):523-6. doi: 10.1016/j.ijantimicag.2008.01.017. Epub 2008 Mar 12.
8
Carbapenem-hydrolyzing oxacillinase, OXA-48, persists in Klebsiella pneumoniae in Istanbul, Turkey.碳青霉烯水解型苯唑西林酶OXA-48在土耳其伊斯坦布尔的肺炎克雷伯菌中持续存在。
Chemotherapy. 2008;54(2):101-6. doi: 10.1159/000118661. Epub 2008 Feb 25.
9
Carbapenemases: molecular diversity and clinical consequences.碳青霉烯酶:分子多样性及临床后果
Future Microbiol. 2007 Oct;2(5):501-12. doi: 10.2217/17460913.2.5.501.
10
Extended-spectrum beta-lactamase CTX-M-1 in Escherichia coli isolates from healthy poultry in France.法国健康家禽分离出的大肠杆菌中存在的超广谱β-内酰胺酶CTX-M-1
Appl Environ Microbiol. 2007 Jul;73(14):4681-5. doi: 10.1128/AEM.02491-06. Epub 2007 May 18.

OXA-48 编码质粒在土耳其及其他地区的传播。

Spread of OXA-48-encoding plasmid in Turkey and beyond.

机构信息

Service de Bactériologie-Virologie, INSERM U914 Emerging Resistance to Antibiotics, Hôpital de Bicêtre, Assistance Publique/Hôpitaux de Paris, Faculté de Médecine Paris Sud, K.-Bicêtre, France.

出版信息

Antimicrob Agents Chemother. 2010 Mar;54(3):1369-73. doi: 10.1128/AAC.01312-09. Epub 2010 Jan 19.

DOI:10.1128/AAC.01312-09
PMID:20086157
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC2825965/
Abstract

Eighteen carbapenem-resistant, OXA-48-positive enterobacterial isolates recovered from Turkey, Lebanon, Egypt, France, and Belgium were analyzed. In most isolates, similar 70-kb plasmids carrying the carbapenemase gene bla(OXA-48) were identified. That gene was located within either transposon Tn1999 or transposon Tn1999.2, which was always inserted within the same gene. This work highlights the current plasmid-mediated dissemination of the OXA-48 carbapenemase worldwide.

摘要

对从土耳其、黎巴嫩、埃及、法国和比利时收集到的 18 株耐碳青霉烯类、产 OXA-48 型金属β-内酰胺酶的肠杆菌进行了分析。在大多数分离株中,发现了携带碳青霉烯酶基因 bla(OXA-48)的类似 70kb 质粒。该基因位于转座子 Tn1999 或转座子 Tn1999.2 内,而这两个转座子通常都插入在同一个基因内。本研究强调了目前 OXA-48 碳青霉烯酶在全球范围内通过质粒介导进行传播。