Service de Bactériologie-Virologie, INSERM U914 Emerging Resistance to Antibiotics, Hôpital de Bicêtre, Assistance Publique/Hôpitaux de Paris, Faculté de Médecine Paris Sud, K.-Bicêtre, France.
Antimicrob Agents Chemother. 2010 Mar;54(3):1369-73. doi: 10.1128/AAC.01312-09. Epub 2010 Jan 19.
Eighteen carbapenem-resistant, OXA-48-positive enterobacterial isolates recovered from Turkey, Lebanon, Egypt, France, and Belgium were analyzed. In most isolates, similar 70-kb plasmids carrying the carbapenemase gene bla(OXA-48) were identified. That gene was located within either transposon Tn1999 or transposon Tn1999.2, which was always inserted within the same gene. This work highlights the current plasmid-mediated dissemination of the OXA-48 carbapenemase worldwide.
对从土耳其、黎巴嫩、埃及、法国和比利时收集到的 18 株耐碳青霉烯类、产 OXA-48 型金属β-内酰胺酶的肠杆菌进行了分析。在大多数分离株中,发现了携带碳青霉烯酶基因 bla(OXA-48)的类似 70kb 质粒。该基因位于转座子 Tn1999 或转座子 Tn1999.2 内,而这两个转座子通常都插入在同一个基因内。本研究强调了目前 OXA-48 碳青霉烯酶在全球范围内通过质粒介导进行传播。