Department of Pediatrics, Newborn Section, Universidade Federal do Rio Grande do Sul and Hospital de Clínicas de Porto Alegre, Porto Alegre, RS, Brazil.
Pediatr Infect Dis J. 2011 Dec;30(12):1052-5. doi: 10.1097/INF.0b013e31822a8662.
To determine the prevalence of Ureaplasma urealyticum and Ureaplasma parvum bacteremia in very low birth weight (VLBW) infants and to evaluate the associated factors.
Ninety-five VLBW newborns with gestational age ≤32 weeks were included in the study conducted between March 2009 and July 2010. DNA was extracted from the blood samples collected during the first 72 hours of life, and U. urealyticum and/or U. parvum were identified by polymerase chain reaction. The newborns were followed up until hospital discharge.
The prevalence of U. urealyticum and/or U. parvum bacteremia was 12.6% (12 cases): 5 (5.2%) for U. urealyticum, 5 (5.2%) for U. parvum, and 2 (2.1%) for both. Based on the univariate analysis, the presence of Ureaplasma was associated with clinical chorioamnionitis and spontaneous preterm labor. Preeclampsia and small for gestational age were associated with lower incidence of Ureaplasma. When spontaneous preterm labor was present, the prevalence of Ureaplasma bacteremia was 25%. Only spontaneous preterm labor was a statistically significant factor after step-by-step logistic regression analysis (P = 0.006), with 9-fold increase in chance of neonatal Ureaplasma bacteremia.
Ureaplasma bacteremia is common in VLBW infants, especially among those born after preterm labor.
确定极低出生体重儿（VLBW）中解脲脲原体和微小脲原体菌血症的患病率，并评估相关因素。
本研究纳入了 2009 年 3 月至 2010 年 7 月期间出生胎龄≤32 周的 95 例 VLBW 新生儿。从出生后 72 小时内采集的血液样本中提取 DNA，通过聚合酶链反应鉴定解脲脲原体和/或微小脲原体。对新生儿进行随访至出院。
解脲脲原体和/或微小脲原体菌血症的患病率为 12.6%（12 例）：解脲脲原体 5 例（5.2%），微小脲原体 5 例（5.2%），两者均有的 2 例（2.1%）。单因素分析显示，解脲脲原体的存在与临床绒毛膜羊膜炎和自发性早产有关。先兆子痫和小于胎龄儿与解脲脲原体的发生率较低有关。自发性早产时，解脲脲原体菌血症的患病率为 25%。只有自发性早产是经过逐步逻辑回归分析后具有统计学意义的因素（P=0.006），新生儿解脲脲原体菌血症的发病几率增加了 9 倍。
解脲脲原体菌血症在 VLBW 婴儿中很常见，尤其是在自发性早产的婴儿中更为常见。
