多年来沙眼衣原体疫苗的研究
Chlamydia trachomatis vaccine research through the years.
作者信息
Schautteet Katelijn, De Clercq Evelien, Vanrompay Daisy
机构信息
Department of Molecular Biotechnology, Faculty of Bioscience Engineering, Ghent University, Coupure Links 653, 9000 Ghent, Belgium.
出版信息
Infect Dis Obstet Gynecol. 2011;2011:963513. doi: 10.1155/2011/963513. Epub 2011 Jun 26.
Abstract
Chlamydia trachomatis is a Gram-negative obligate intracellular bacterium. It is the leading cause of bacterial sexual transmitted infections (STIs). World Health Organization figures estimated that over 90 million new cases of genital C. trachomatis infections occur worldwide each year. A vaccination program is considered to be the best approach to reduce the prevalence of C. trachomatis infections, as it would be much cheaper and have a greater impact on controlling C. trachomatis infections worldwide rather than a screening program or treating infections with antibiotics. Currently, there are no vaccines available which effectively protect against a C. trachomatis genital infection despite the many efforts that have been made throughout the years. In this paper, the many attempts to develop a protective vaccine against a genital C. trachomatis infection will be reviewed.
摘要
沙眼衣原体是一种革兰氏阴性专性细胞内细菌。它是细菌性性传播感染（STIs）的主要病因。世界卫生组织的数据估计，全球每年有超过9000万例新的生殖道人型沙眼衣原体感染病例。疫苗接种计划被认为是降低沙眼衣原体感染流行率的最佳方法，因为它比筛查计划或用抗生素治疗感染要便宜得多，并且对全球控制沙眼衣原体感染有更大的影响。目前，尽管多年来人们付出了诸多努力，但仍没有可有效预防生殖道人型沙眼衣原体感染的疫苗。在本文中，将对开发针对生殖道人型沙眼衣原体感染的保护性疫苗的诸多尝试进行综述。
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本文引用的文献
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Immunization with live and dead Chlamydia muridarum induces different levels of protective immunity in a murine genital tract model: correlation with MHC class II peptide presentation and multifunctional Th1 cells.用活的和死的鼠衣原体免疫可在小鼠生殖道模型中诱导不同水平的保护性免疫：与 MHC Ⅱ类肽呈递和多功能 Th1 细胞相关。
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