Radlberger Philipp, Adlbrecht Christopher, Mittermayr Tarquin
Ludwig Boltzmann Institut - Health Technology Assessment;
Exp Clin Cardiol. 2011 Summer;16(2):43-6.
Cardiac contractility modulation in patients with heart failure refractory to drug treatment aims to strengthen myocardial activity through transmission of nonexcitatory impulses to the heart. The present study reviewed a total of 251 patients from four studies; the results, however, showed a low level of evidence. Crossover analysis showed a strong placebo effect for patients with implants that were switched on after three months. The technology is still in the development stage and further studies are needed.
对于药物治疗难治性心力衰竭患者，心脏收缩力调制旨在通过向心脏传递非兴奋性冲动来增强心肌活动。本研究回顾了四项研究中的总共251名患者；然而，结果显示证据水平较低。交叉分析表明，对于植入装置在三个月后开启的患者，存在较强的安慰剂效应。该技术仍处于研发阶段，需要进一步研究。
