Ashraf Muhammad Waseem, Tayyaba Shahzadi, Afzulpurkar Nitin
School of Engineering and Technology, Asian Institute of Technology (AIT), Bangkok 12120, Thailand; E-Mails:
Int J Mol Sci. 2011;12(6):3648-704. doi: 10.3390/ijms12063648. Epub 2011 Jun 7.
Micro Electromechanical Systems (MEMS) based microfluidic devices have gained popularity in biomedicine field over the last few years. In this paper, a comprehensive overview of microfluidic devices such as micropumps and microneedles has been presented for biomedical applications. The aim of this paper is to present the major features and issues related to micropumps and microneedles, e.g., working principles, actuation methods, fabrication techniques, construction, performance parameters, failure analysis, testing, safety issues, applications, commercialization issues and future prospects. Based on the actuation mechanisms, the micropumps are classified into two main types, i.e., mechanical and non-mechanical micropumps. Microneedles can be categorized according to their structure, fabrication process, material, overall shape, tip shape, size, array density and application. The presented literature review on micropumps and microneedles will provide comprehensive information for researchers working on design and development of microfluidic devices for biomedical applications.
在过去几年中，基于微机电系统（MEMS）的微流控装置在生物医学领域越来越受欢迎。本文对用于生物医学应用的微流控装置，如微型泵和微针进行了全面概述。本文的目的是介绍与微型泵和微针相关的主要特征和问题，例如工作原理、驱动方法、制造技术、结构、性能参数、故障分析、测试、安全问题、应用、商业化问题和未来前景。基于驱动机制，微型泵主要分为两种类型，即机械微型泵和非机械微型泵。微针可以根据其结构、制造工艺、材料、整体形状、尖端形状、尺寸、阵列密度和应用进行分类。本文对微型泵和微针的文献综述将为从事生物医学应用微流控装置设计和开发的研究人员提供全面信息。
