Viana-Baptista Miguel, Bugalho Paulo, Jordão Constança, Ribeiro Olga, Esperança-Pina José António, Ferro José
Neurology Department, Hospital de Egas Moniz (CHLO), 1349-019 Lisbon, Portugal.
J Aging Res. 2011;2011:950341. doi: 10.4061/2011/950341. Epub 2011 May 15.
Objectives. To test the relation between white matter lesions (WML) location and physical performance, in aged patients. Methods.
29 patients (17 males), aged >65 (mean age 72.6 ± 5.2), with leukoaraiosis. WML was quantified with a visual scale; Apparent Diffusion Coefficient (ADC) was measured bilaterally in frontal periventricular lesioned white matter and frontal and parieto-occipital normal appearing white matter (NAWM). Motor performance was studied using the Short Physical Performance Battery (SPPB), single leg stand time, finger tapping and grooved pegboard tests (GPT). Results. There were significant correlations between the frontal region visual scale scores and SPPB chair stands (r = -0.379; P = .039) and Grooved Pegboard (r = 0.393; P = .032); frontal NAWM ADC values and SPPB standing balance (r = -0.450; P = .014) and SPPB 4 meter walk (r = -0.379; P = .043). Conclusion. Frontal WML are negatively related to motor performance in patients with leukoaraiosis. DWI results suggest that this may be true even for NAWM.
目的。测试老年患者白质病变（WML）位置与身体机能之间的关系。方法。
29例患者（17例男性），年龄>65岁（平均年龄72.6±5.2岁），患有脑白质疏松症。采用视觉量表对白质病变进行量化；在双侧额叶脑室周围病变白质以及额叶和顶枕叶正常白质（NAWM）中测量表观扩散系数（ADC）。使用简短身体机能测试量表（SPPB）、单腿站立时间、手指敲击和槽式钉板测试（GPT）研究运动机能。结果。额叶区域视觉量表评分与SPPB椅子起立测试（r = -0.379；P = 0.039）和槽式钉板测试（r = 0.393；P = 0.032）之间存在显著相关性；额叶正常白质ADC值与SPPB站立平衡（r = -0.450；P = 0.014）和SPPB 4米步行测试（r = -0.379；P = 0.043）之间存在显著相关性。结论。额叶白质病变与脑白质疏松症患者的运动机能呈负相关。弥散加权成像（DWI）结果表明，即使对于正常白质也是如此。
