高钠饮食对大鼠肾细胞膜细胞体积及钠刺激的ATP酶活性的影响。
Effect of a high Na+ diet on cell volume and Na(+)-stimulated ATPase activities of rat kidney membranes.
作者信息
Di Campo V, Henríquez L M, Proverbio T, Marín R, Proverbio F
机构信息
Centro de Biofísica y Bioquímica, Instituto Venezolano de Investigacions Científicas (IVIC), Caracas, Venezuela.
出版信息
FEBS Lett. 1990 Nov 12;274(1-2):96-8. doi: 10.1016/0014-5793(90)81338-o.
Proximal tubular cells from kidneys of male rats chronically fed with an isotonic NaCl solution, show a volume increase which is dependent on the length of the treatment with NaCl, when compared with control rats. Parallel to the cell volume increase, there is an increase of the ouabain-insensitive Na-ATPase activity, whereas the ouabain-sensitive Na,K-ATPase activity remains unchanged. These results establish a clear relationship between a chronic Na-diet, kidney cell volume and Na-ATPase activity.
与对照大鼠相比，长期喂食等渗氯化钠溶液的雄性大鼠肾脏近端小管细胞显示出体积增加，该增加取决于氯化钠处理的时长。与细胞体积增加同时发生的是，哇巴因不敏感的钠-ATP酶活性增加，而哇巴因敏感的钠钾-ATP酶活性保持不变。这些结果确立了慢性钠饮食、肾细胞体积和钠-ATP酶活性之间的明确关系。
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