Al-Jabri Ali A
Department of Microbiology & Immunology, College of Medicine & Health Sciences, Sultan Qaboos University, P.O. Box 35, PC 123, Al-Khod, Muscat, Sultanate of Oman.
Sultan Qaboos Univ Med J. 2007 Aug;7(2):82-96.
Since the discovery in the early eighties of the Human Immunodeficiency Virus (HIV) that causes acquired immunodeficiency syndrome (AIDS), there have been reports of people who were completely resistant to infection with HIV and others who progressed at slower rates to AIDS. The present article summarises the mechanisms involved in resistance against HIV infection and progression to AIDS. The paper will specifically focus on the role of immunological mechanisms, genetics, ethnicity and cultural practices such as male circumcision in mitigating infection. The current understanding on host natural resistance against HIV infection and progression to AIDS would potentially contribute to better prevention strategies, delayed onset of AIDS in people living with HIV, the identification of more efficient types of therapy for AIDS patients and, possibly, appropriate vaccines against HIV/AIDS. This area of research has important implications for patient care through controlling factors that contribute to AIDS progression.
自20世纪80年代初发现导致获得性免疫缺陷综合征（艾滋病）的人类免疫缺陷病毒（HIV）以来，一直有关于对HIV感染完全具有抗性的人和以较慢速度发展为艾滋病的人的报道。本文总结了抵抗HIV感染和发展为艾滋病所涉及的机制。该论文将特别关注免疫机制、遗传学、种族以及诸如男性包皮环切术等文化习俗在减轻感染方面的作用。目前对宿主对HIV感染和发展为艾滋病的天然抗性的理解可能有助于制定更好的预防策略、延缓HIV感染者患艾滋病的时间、确定针对艾滋病患者更有效的治疗类型，并可能研发出针对HIV/艾滋病的合适疫苗。这一研究领域通过控制导致艾滋病进展的因素，对患者护理具有重要意义。
