放射治疗中质子对v79细胞失活截面的计算
Calculation of the inactivation cross section of v79 cells by protons in radiotherapy.
作者信息
Azooz Faika A, Alkhalidy Thamer J
机构信息
Department of Physics, College of Education, University of Mosul, Iraq.
出版信息
Sultan Qaboos Univ Med J. 2007 Dec;7(3):233-8.
OBJECTIVE
For efficient applications of protons in radiotherapy, detailed knowledge of the corresponding radiobiological mechanism is necessary. The inactivation cross section is a useful tool to explore the interaction mechanism. Hence, the inactivation cross section for proton irradiation on V79 cells has been calculated using published survival data.
METHOD
The linear quadratic equation was used to fit the survival curves and the parameter α was used to calculate the cross section. The cross section σ is plotted as a function of the mean free path λ and the linear energy transfer LET.
RESULTS
The cross section σ-versus-λ curve shows a saturation region between λ≥2 nm and λ≤5 nm. In this region, the inactivation cross section value is about the same as the geometrical area of the DNA segment (≈4 μm(2)). Such a saturation is also seen in the σ-LET curve.
CONCLUSION
This implies that one DNA segment is at a risk upon the traversal of a single proton.
目的
为了在放射治疗中有效地应用质子，详细了解相应的放射生物学机制是必要的。失活截面是探索相互作用机制的有用工具。因此，已根据已发表的存活数据计算了质子辐照V79细胞的失活截面。
方法
使用线性二次方程拟合存活曲线，并使用参数α计算截面。将截面σ绘制为平均自由程λ和线能量转移LET的函数。
结果
σ与λ曲线在λ≥2nm和λ≤5nm之间显示出一个饱和区域。在该区域中，失活截面值与DNA片段的几何面积（≈4μm²）大致相同。在σ-LET曲线中也观察到这种饱和现象。
结论
这意味着单个质子穿过时，一个DNA片段会处于危险之中。
Zotero 插件