Department of Chemistry, The University of Western Ontario, Ontario, London, Canada N6A 5B7.
Chem Commun (Camb). 2011 Aug 28;47(32):9194-6. doi: 10.1039/c1cc13073k. Epub 2011 Jul 11.
Contrast agents based on lanthanide tetra-propargyl DOTAM complexes suitable for temperature mapping by magnetic resonance spectroscopy (MRS) are reported. Sensitivity values from 1.05 ppm/°C to 1.76 ppm/°C were determined which represents an improvement of 2-3 times over currently available lanthanide temperature-responsive contrast agents.
报道了基于镧系元素四炔丙基 DOTAM 配合物的对比剂，适用于磁共振波谱（MRS）的温度测绘。确定的灵敏度值在 1.05 ppm/°C 至 1.76 ppm/°C 之间，相比于当前可用的镧系元素温度响应对比剂提高了 2-3 倍。
