School of Chemistry and Bio21 Molecular Science and Biotechnology Institute, University of Melbourne, Parkville, Victoria, Australia.
Org Biomol Chem. 2011 Sep 7;9(17):6082-8. doi: 10.1039/c1ob05360d. Epub 2011 Jul 12.
Silver acetylides and organic azides react under copper(I) catalysis to afford 1,4-disubstituted 1,2,3-triazoles. Mechanistic studies implicate a process involving transmetallation to copper acetylides prior to cycloaddition. This work demonstrates that silver acetylides serve as suitable precursors for entry into copper-mediated coupling reactions. This methodology allows the incorporation of volatile and difficult-to-handle acetylenes into the triazole core.
银乙酰化物和有机叠氮化物在铜（I）催化下反应，生成 1,4-取代的 1,2,3-三唑。机理研究表明，该过程涉及到铜乙酰化物的转金属化，然后再进行环加成反应。这项工作证明了银乙酰化物是铜介导偶联反应的合适前体。该方法允许将挥发性和难以处理的炔烃引入三唑核心。
