Division of Nephrology, Niguarda Ca' Granda Hospital, Milan, Italy.
J Nephrol. 2011 Nov-Dec;24(6):707-16. doi: 10.5301/jn.5000004.
After 50 years, the incidence of lymphocele and lymphorrhea associated with renal transplantation remains substantially high in spite of more accurate surgical technique, reduction of other complications and improvement of general outcomes. The data from the literature point to the allograft as the source of increased lymph production, which in spite of an accurate hilar lymphatics ligature, can find a transcapsular outlet. Subclinical and clinical graft rejection and inflammation greatly enhance lymph production and leakage. This mechanism may partially mediate the effects of some immunosuppressive drugs on the incidence of lymphocele.
尽管手术技术更加精确、其他并发症减少以及整体结果改善,但是与肾移植相关的淋巴囊肿和淋巴漏的发生率在 50 年后仍然很高。文献中的数据表明,移植物是增加淋巴生成的来源,尽管准确地结扎了肾门淋巴管,但仍可以找到经包膜下的流出途径。亚临床和临床移植物排斥和炎症大大增加了淋巴生成和渗漏。这种机制可能部分解释了一些免疫抑制药物对淋巴囊肿发生率的影响。