阿尔茨海默病：疾病严重程度全谱的诊断与治疗
Alzheimer's disease: diagnosis and treatment across the spectrum of disease severity.
作者信息
Neugroschl Judith, Wang Sophia
机构信息
Mount Sinai School of Medicine, New York, NY, USA.
出版信息
Mt Sinai J Med. 2011 Jul-Aug;78(4):596-612. doi: 10.1002/msj.20279.
Abstract
Alzheimer's disease exists along a spectrum, from early memory changes to functional dependence and death. Using a case illustration, we review the evaluation and diagnosis of mild cognitive impairment and the diagnosis and management of Alzheimer's disease at each stage, including the management of both cognitive and behavioral/psychiatric aspects of the disease and end-stage and end-of-life care.
摘要
阿尔茨海默病呈现出一个连续谱，从早期的记忆变化到功能依赖直至死亡。通过一个病例说明，我们回顾了轻度认知障碍的评估与诊断以及阿尔茨海默病各阶段的诊断与管理，包括该疾病认知和行为/精神方面的管理以及终末期和临终关怀。
相似文献
1
Alzheimer's disease: diagnosis and treatment across the spectrum of disease severity.阿尔茨海默病：疾病严重程度全谱的诊断与治疗
Mt Sinai J Med. 2011 Jul-Aug;78(4):596-612. doi: 10.1002/msj.20279.
2
[Behavioural and psychological symptoms in dementia in Alzheimer's disease].[阿尔茨海默病性痴呆中的行为和心理症状]
Rev Prat. 2005 Nov 15;55(17):1895-901.
3
Neuropsychological assessment in the diagnosis of Alzheimer's disease.阿尔茨海默病诊断中的神经心理学评估
Curr Protoc Neurosci. 2009 Oct;Chapter 10:Unit10.3. doi: 10.1002/0471142301.ns1003s49.
4
Alzheimer's disease management.阿尔茨海默病管理
J Clin Psychiatry. 1998;59 Suppl 13:36-8.
5
The effects of metrifonate on the cognitive, behavioral, and functional performance of Alzheimer's disease patients. Metrifonate Study Group.敌百虫对阿尔茨海默病患者认知、行为及功能表现的影响。敌百虫研究小组。
J Clin Psychiatry. 1999 May;60(5):318-25. doi: 10.4088/jcp.v60n0510.
6
Interventions and diagnostics in Alzheimer's disease and related conditions.阿尔茨海默病及相关病症的干预措施与诊断方法
Am J Alzheimers Dis Other Demen. 2010 Mar;25(2):107-8. doi: 10.1177/1533317510363778.
7
The clinical syndrome of Alzheimer's disease: aspects particularly relevant to clinical trials.阿尔茨海默病的临床综合征：与临床试验特别相关的方面。
Genes Brain Behav. 2005 Apr;4(3):129-33. doi: 10.1111/j.1601-183X.2004.00112.x.
8
Current evidence for subjective cognitive impairment (SCI) as the pre-mild cognitive impairment (MCI) stage of subsequently manifest Alzheimer's disease.目前关于主观认知障碍（SCI）作为随后出现的阿尔茨海默病轻度认知障碍（MCI）前期阶段的证据。
Int Psychogeriatr. 2008 Feb;20(1):1-16. doi: 10.1017/S1041610207006412.
9
Differential diagnosis of depression and Alzheimer's disease with the Addenbrooke's Cognitive Examination-Revised (ACE-R).使用修订版Addenbrooke认知检查（ACE-R）对抑郁症和阿尔茨海默病进行鉴别诊断。
BMC Neurol. 2015 Apr 17;15:57. doi: 10.1186/s12883-015-0315-3.
10
Impact of psychiatric hospitalization on behavioral complications of Alzheimer's disease.
Am J Psychiatry. 1992 Nov;149(11):1484-91. doi: 10.1176/ajp.149.11.1484.
引用本文的文献
1
Caudal and Thalamic Segregation in White Matter Brain Network Communities in Alzheimer's Disease Population.阿尔茨海默病患者脑白质网络社区中的尾侧与丘脑分离
IEEE EMBS Int Conf Biomed Health Inform. 2024 Nov;2024. doi: 10.1109/bhi62660.2024.10913835. Epub 2025 Mar 17.
2
Microglial activation states and their implications for Alzheimer's Disease.小胶质细胞激活状态及其对阿尔茨海默病的影响。
J Prev Alzheimers Dis. 2025 Jan;12(1):100013. doi: 10.1016/j.tjpad.2024.100013. Epub 2025 Jan 1.
3
Liposomal Formulations of Anti-Alzheimer Drugs and siRNA for Nose-to-Brain Delivery: Design, Safety and Efficacy In Vitro.载药脂质体和 siRNA 鼻腔递药系统治疗阿尔茨海默病：设计、安全性和体外有效性。
AAPS J. 2024 Sep 4;26(5):99. doi: 10.1208/s12248-024-00967-x.
4
Alzheimer's disease: a review on the current trends of the effective diagnosis and therapeutics.阿尔茨海默病：有效诊断与治疗的当前趋势综述
Front Aging Neurosci. 2024 Aug 9;16:1429211. doi: 10.3389/fnagi.2024.1429211. eCollection 2024.
5
Effects silymarin and rosuvastatin on amyloid-carriers level in dyslipidemic Alzheimer's patients: A double-blind placebo-controlled randomized clinical trial.水飞蓟素和瑞舒伐他汀对血脂异常的阿尔茨海默病患者淀粉样蛋白携带者水平的影响：一项双盲安慰剂对照随机临床试验。
IBRO Neurosci Rep. 2024 Jul 20;17:108-121. doi: 10.1016/j.ibneur.2024.07.002. eCollection 2024 Dec.
6
Deep Ensemble learning and quantum machine learning approach for Alzheimer's disease detection.深度集成学习和量子机器学习方法在阿尔茨海默病检测中的应用。
Sci Rep. 2024 Jun 20;14(1):14196. doi: 10.1038/s41598-024-61452-1.
7
Memory enhancing and neuroprotective effects of apomorphine in a rat model of dementia.阿朴吗啡对痴呆大鼠模型的记忆增强和神经保护作用。
Metab Brain Dis. 2024 Aug;39(6):1051-1063. doi: 10.1007/s11011-024-01372-1. Epub 2024 Jun 19.
8
Advancing diagnostic performance and clinical applicability of deep learning-driven generative adversarial networks for Alzheimer's disease.提高深度学习驱动的生成对抗网络在阿尔茨海默病诊断中的性能和临床适用性。
Psychoradiology. 2021 Dec 23;1(4):225-248. doi: 10.1093/psyrad/kkab017. eCollection 2021 Dec.
9
Leveraging electronic health records and knowledge networks for Alzheimer's disease prediction and sex-specific biological insights.利用电子健康记录和知识网络进行阿尔茨海默病预测和性别特异性生物学研究。
Nat Aging. 2024 Mar;4(3):379-395. doi: 10.1038/s43587-024-00573-8. Epub 2024 Feb 21.
10
Bayesian workflow for the investigation of hierarchical classification models from tau-PET and structural MRI data across the Alzheimer's disease spectrum.用于研究阿尔茨海默病谱系中tau正电子发射断层扫描（tau-PET）和结构磁共振成像（MRI）数据的分层分类模型的贝叶斯工作流程。
Front Aging Neurosci. 2023 Oct 18;15:1225816. doi: 10.3389/fnagi.2023.1225816. eCollection 2023.
本文引用的文献
1
2011 Alzheimer's disease facts and figures.2011 年阿尔茨海默病事实和数据。
Alzheimers Dement. 2011 Mar;7(2):208-44. doi: 10.1016/j.jalz.2011.02.004.
2
Antidepressants for agitation and psychosis in dementia.用于治疗痴呆症激越和精神病的抗抑郁药。
Cochrane Database Syst Rev. 2011 Feb 16(2):CD008191. doi: 10.1002/14651858.CD008191.pub2.
3
Use of florbetapir-PET for imaging beta-amyloid pathology.氟代脱氧葡萄糖-PET 用于成像β淀粉样蛋白病理。
JAMA. 2011 Jan 19;305(3):275-83. doi: 10.1001/jama.2010.2008.
4
Neuropsychiatric symptoms in MCI subtypes: the importance of executive dysfunction.MCI 亚型中的神经精神症状：执行功能障碍的重要性。
Int J Geriatr Psychiatry. 2011 Apr;26(4):364-72. doi: 10.1002/gps.2535. Epub 2010 Sep 15.
5
Perceptions of depression among dementia caregivers: findings from the CATIE-AD trial.痴呆症照顾者对抑郁的认知：来自 CATIE-AD 试验的结果。
Int J Geriatr Psychiatry. 2011 Apr;26(4):397-402. doi: 10.1002/gps.2539. Epub 2010 Sep 15.
6
Prevalence of mild cognitive impairment is higher in men. The Mayo Clinic Study of Aging.男性轻度认知障碍的患病率较高。梅奥诊所老龄化研究。
Neurology. 2010 Sep 7;75(10):889-97. doi: 10.1212/WNL.0b013e3181f11d85.
7
Neuropsychiatric symptoms and syndromes in a large cohort of newly diagnosed, untreated patients with Alzheimer disease.阿尔茨海默病初诊未治疗患者大样本中神经精神症状和综合征。
Am J Geriatr Psychiatry. 2010 Nov;18(11):1026-35. doi: 10.1097/JGP.0b013e3181d6b68d.
8
Effectiveness and tolerability of high-dose (23 mg/d) versus standard-dose (10 mg/d) donepezil in moderate to severe Alzheimer's disease: A 24-week, randomized, double-blind study.高剂量（23 毫克/天）与标准剂量（10 毫克/天）多奈哌齐治疗中重度阿尔茨海默病的有效性和耐受性：一项 24 周、随机、双盲研究。
Clin Ther. 2010 Jul;32(7):1234-51. doi: 10.1016/j.clinthera.2010.06.019.
9
Depressive symptoms and risk of dementia: the Framingham Heart Study.抑郁症状与痴呆风险：弗雷明汉心脏研究。
Neurology. 2010 Jul 6;75(1):35-41. doi: 10.1212/WNL.0b013e3181e62138.
10
Recurrent depressive symptoms and the incidence of dementia and mild cognitive impairment.复发性抑郁症状与痴呆和轻度认知障碍的发生率。
Neurology. 2010 Jul 6;75(1):27-34. doi: 10.1212/WNL.0b013e3181e62124.
Zotero 插件