• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利：CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法，用中文像聊天一样搜索，搜遍4000万医学文献。AI智能推荐，让科研检索更轻松。

立即免费搜索

文件翻译

保留排版，准确专业，支持PDF/Word/PPT等文件格式，支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述，25分钟生成高质量综述，智能提取关键信息，辅助科研写作。

立即免费体验

相似文献

1
Padanamides A and B, highly modified linear tetrapeptides produced in culture by a Streptomyces sp. isolated from a marine sediment.帕丹酰胺 A 和 B，由从海洋沉积物中分离出的链霉菌属产生的高度修饰的线性四肽。
Org Lett. 2011 Aug 5;13(15):3936-9. doi: 10.1021/ol2014494. Epub 2011 Jul 12.
2
N-carbamoylation of 2,4-diaminobutyrate reroutes the outcome in padanamide biosynthesis.2,4-二氨基丁酸的N-氨甲酰化改变了帕达酰胺生物合成的结果。
Chem Biol. 2013 Aug 22;20(8):1002-11. doi: 10.1016/j.chembiol.2013.06.013. Epub 2013 Aug 1.
3
Total synthesis of padanamides A and B.帕丹酰胺 A 和 B 的全合成。
Chem Commun (Camb). 2013 Apr 14;49(29):2977-9. doi: 10.1039/c3cc00178d.
4
JBIR-150, a novel 20-membered polyene macrolactam from marine-derived Streptomyces sp. OPMA00071.海洋来源的链霉菌 OPMA00071 中产生的新型 20 元聚烯大环内酯 JBIR-150。
J Antibiot (Tokyo). 2018 Mar;71(3):390-392. doi: 10.1038/s41429-017-0010-2. Epub 2018 Jan 18.
5
Nahuoic acid A produced by a Streptomyces sp. isolated from a marine sediment is a selective SAM-competitive inhibitor of the histone methyltransferase SETD8.海洋沉积物中分离得到的链霉菌产生的纳霍酸 A 是组蛋白甲基转移酶 SETD8 的选择性 SAM 竞争抑制剂。
Org Lett. 2013 Jan 18;15(2):414-7. doi: 10.1021/ol303416k. Epub 2012 Dec 28.
6
03219A, a new Δ(8,9)-pregnene isolated from Streptomyces sp. SCSIO 03219 obtained from a South China Sea sediment.从南海沉积物中分离得到的一株链霉菌（Streptomyces sp. SCSIO 03219）中提取的一种新的 Δ(8,9)-孕烯，编号为 03219A。
J Antibiot (Tokyo). 2013 Jun;66(6):327-31. doi: 10.1038/ja.2013.15. Epub 2013 Apr 3.
7
Tetrapeptides possessing a unique skeleton, JBIR-34 and JBIR-35, isolated from a sponge-derived actinomycete, Streptomyces sp. Sp080513GE-23.从海绵来源放线菌 Streptomyces sp. Sp080513GE-23 中分离得到具有独特骨架的四肽 JBIR-34 和 JBIR-35。
J Nat Prod. 2010 Feb 26;73(2):226-8. doi: 10.1021/np900810r.
8
Isolation and structure determination of streptochlorin, an antiproliferative agent from a marine-derived Streptomyces sp. 04DH110.从海洋来源的链霉菌属菌株04DH110中分离得到抗增殖剂链绿菌素及其结构鉴定。
J Microbiol Biotechnol. 2007 Aug;17(8):1403-6.
9
Characterization of cytotoxic compound from marine sediment derived actinomycete Streptomyces avidinii strain SU4.从海洋沉积物来源的放线菌阿维链霉菌SU4菌株中分离出的细胞毒性化合物的特性研究
Asian Pac J Trop Biomed. 2012 Oct;2(10):770-3. doi: 10.1016/S2221-1691(12)60227-5.
10
Donghaecyclinones A-C: New Cytotoxic Rearranged Angucyclinones from a Volcanic Island-Derived Marine sp.东海环康定 A-C：来自火山岛源海洋 sp 的新型细胞毒性重排安吉环酮
Mar Drugs. 2020 Feb 18;18(2):121. doi: 10.3390/md18020121.

引用本文的文献

1
Screening and hit evaluation of a microbial metabolite library against the pathogenic Plasmodium falciparum and Toxoplasma gondii parasites.针对致病性恶性疟原虫和刚地弓形虫寄生虫对微生物代谢产物文库进行筛选和活性评估。
Int J Parasitol Drugs Drug Resist. 2025 Aug 5;29:100606. doi: 10.1016/j.ijpddr.2025.100606.
2
Access to Nitrogen-nitrogen Bond-Containing Heterocycles Through Substrate Promiscuity of Piperazate Synthases.通过哌嗪酸合酶的底物通用性获得含氮氮键的杂环化合物。
ACS Catal. 2025 May 12;15(11):8846-8854. doi: 10.1021/acscatal.5c01237. eCollection 2025 Jun 6.
3
Functional Diversity and Engineering of the Adenylation Domains in Nonribosomal Peptide Synthetases.非核糖体肽合成酶中腺苷酸结构域的功能多样性与工程改造。
Mar Drugs. 2024 Jul 29;22(8):349. doi: 10.3390/md22080349.
4
Bioactive metabolites identification of the foxnut and broken millet-based nutritional bar using HR-MS.采用高分辨质谱法对基于芡实和碎小米的营养棒进行生物活性代谢物鉴定。
Food Chem (Oxf). 2024 Jul 17;9:100214. doi: 10.1016/j.fochms.2024.100214. eCollection 2024 Dec 30.
5
()-3-aminopiperidine-2,6-dione is a biosynthetic intermediate of microbial blue pigment indigoidine.（）-3-氨基哌啶-2,6-二酮是微生物蓝色色素靛蓝素的生物合成中间体。
mLife. 2022 Jun 21;1(2):146-155. doi: 10.1002/mlf2.12023. eCollection 2022 Jun.
6
The use of nitrogen-15 in microbial natural product discovery and biosynthetic characterization.氮-15在微生物天然产物发现及生物合成表征中的应用。
Front Microbiol. 2023 May 10;14:1174591. doi: 10.3389/fmicb.2023.1174591. eCollection 2023.
7
Cytotoxic compounds from marine actinomycetes: Sources, Structures and Bioactivity.海洋放线菌产生的细胞毒性化合物：来源、结构与生物活性
Acta Mater Med. 2022;1(4):445-475. doi: 10.15212/amm-2022-0028. Epub 2022 Nov 15.
8
Bioactive Microbial Metabolites in Cancer Therapeutics: Mining, Repurposing, and Their Molecular Targets.癌症治疗中的生物活性微生物代谢产物：挖掘、再利用及其分子靶点。
Curr Microbiol. 2022 Aug 24;79(10):300. doi: 10.1007/s00284-022-02990-7.
9
Bioproduction of L-piperazic acid in gram scale using Aureobasidium melanogenum.利用嗜热枝孢霉在克级规模生产 L-哌嗪酸。
Microb Biotechnol. 2021 Jul;14(4):1722-1729. doi: 10.1111/1751-7915.13838. Epub 2021 Jun 3.
10
Recent Advances in Small Peptides of Marine Origin in Cancer Therapy.海洋源小肽在癌症治疗中的最新进展
Mar Drugs. 2021 Feb 19;19(2):115. doi: 10.3390/md19020115.

本文引用的文献

1
Antibacterials from the sea.海洋来源的抗菌药物。
Chemistry. 2010 Nov 8;16(42):12512-25. doi: 10.1002/chem.201001279.
2
Highly-multiplexed barcode sequencing: an efficient method for parallel analysis of pooled samples.高多重条码测序：一种用于并行分析混合样本的高效方法。
Nucleic Acids Res. 2010 Jul;38(13):e142. doi: 10.1093/nar/gkq368. Epub 2010 May 11.
3
The genetic landscape of a cell.细胞的基因图谱。
Science. 2010 Jan 22;327(5964):425-31. doi: 10.1126/science.1180823.
4
Plectosphaeroic acids A, B, and C, indoleamine 2,3-dioxygenase inhibitors produced in culture by a marine isolate of the fungus Plectosphaerella cucumerina.
Org Lett. 2009 Jul 16;11(14):2996-9. doi: 10.1021/ol900972j.
5
Determination of absolute structure using Bayesian statistics on Bijvoet differences.利用贝叶斯统计法基于对映体差值确定绝对结构
J Appl Crystallogr. 2008 Feb 1;41(Pt 1):96-103. doi: 10.1107/S0021889807059870. Epub 2008 Jan 16.
6
Tauramamide, a lipopeptide antibiotic produced in culture by Brevibacillus laterosporus isolated from a marine habitat: structure elucidation and synthesis.陶拉酰胺，一种从海洋栖息地分离出的短芽孢杆菌在培养过程中产生的脂肽抗生素：结构解析与合成。
J Nat Prod. 2007 Dec;70(12):1850-3. doi: 10.1021/np070209r. Epub 2007 Nov 29.
7
Exploring the mode-of-action of bioactive compounds by chemical-genetic profiling in yeast.通过酵母中的化学遗传学分析探索生物活性化合物的作用模式。
Cell. 2006 Aug 11;126(3):611-25. doi: 10.1016/j.cell.2006.06.040.
8
Solid-phase synthesis of bleomycin group antibiotics. Construction of a 108-member deglycobleomycin library.博来霉素类抗生素的固相合成。构建一个包含108个成员的去糖博来霉素文库。
J Am Chem Soc. 2003 Jul 9;125(27):8218-27. doi: 10.1021/ja021388w.
9
Tupuseleiamides and basiliskamides, new acyldipeptides and antifungal polyketides produced in culture by a Bacillus laterosporus isolate obtained from a tropical marine habitat.
J Nat Prod. 2002 Oct;65(10):1447-51. doi: 10.1021/np0201321.
10
Bogorol A produced in culture by a marine Bacillus sp. reveals a novel template for cationic peptide antibiotics.
Org Lett. 2001 Feb 8;3(3):437-40. doi: 10.1021/ol006942q.

帕丹酰胺 A 和 B，由从海洋沉积物中分离出的链霉菌属产生的高度修饰的线性四肽。

Padanamides A and B, highly modified linear tetrapeptides produced in culture by a Streptomyces sp. isolated from a marine sediment.

机构信息

Department of Chemistry, University of British Columbia, Vancouver, BC, Canada, V6T 1Z1.

出版信息

Org Lett. 2011 Aug 5;13(15):3936-9. doi: 10.1021/ol2014494. Epub 2011 Jul 12.

DOI:10.1021/ol2014494
PMID:21749075
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC3152301/
Abstract

Two highly modified linear tetrapeptides, padanamides A (1) and B (2), are produced by laboratory cultures of a Streptomyces sp. obtained from a marine sediment. Padanamide B is cytotoxic to Jurkat cells, and a chemical genomics analysis using Saccharomyces cerevisiae deletion mutants suggested that padanamide A inhibits cysteine and methionine biosynthesis or that these amino acids are involved in the yeast's response to the peptide.

摘要

两种高度修饰的线性四肽，帕丹酰胺 A（1）和 B（2），是由从海洋沉积物中获得的链霉菌属实验室培养物产生的。帕丹酰胺 B 对 Jurkat 细胞具有细胞毒性，使用酿酒酵母缺失突变体的化学基因组学分析表明，帕丹酰胺 A 抑制半胱氨酸和蛋氨酸生物合成，或者这些氨基酸参与了酵母对该肽的反应。