Koren Gideon, Maltepe Caroline, Gow Rachel
Motherisk Program, Hospital for Sick Children, Toronto ON.
J Obstet Gynaecol Can. 2011 Jul;33(7):733-735. doi: 10.1016/S1701-2163(16)34960-X.
With 80% of pregnant women suffering from some degree of "morning sickness," or nausea and vomiting of pregnancy (NVP), symptom management is a major challenge. A recent Cochrane systematic review of randomized controlled trials concluded that, to date, there is no strong evidence of effectiveness for practically any therapeutic agent used for management of NVP. Because of fears of teratogenicity and litigation, RCTs are rarely conducted in pregnancy. In the absence of the best possible evidence from RCTs, well planned and executed prospective observational studies should be used as the best available evidence to guide clinical practice.
80%的孕妇会出现某种程度的“晨吐”，即妊娠恶心和呕吐（NVP），症状管理是一项重大挑战。Cochrane最近对随机对照试验进行的系统评价得出结论，迄今为止，几乎没有确凿证据表明用于管理NVP的任何治疗药物有效。由于担心致畸性和诉讼，很少在孕期进行随机对照试验。在缺乏随机对照试验的最佳证据的情况下，精心规划和实施的前瞻性观察性研究应用作指导临床实践的最佳现有证据。
