Madjunkova Svetlana, Maltepe Caroline, Koren Gideon
The Motherisk Program, Division of Clinical Pharmacology/Toxicology, The Hospital for Sick Children, The University of Toronto, 555 University Avenue, Toronto, ON, Canada M5G 1X8.
Obstet Gynecol Int. 2013;2013:752980. doi: 10.1155/2013/752980. Epub 2013 Apr 15.
Background. Nausea and vomiting of pregnancy (NVP) is the most common medical condition of pregnancy, affecting up to 85% of expecting mothers. In the USA, there is no FDA-approved medication for the treatment of NVP. Objective. To identify the primary concerns of American women leading them to contact the Motherisk NVP Helpline and to characterize the severity of their symptoms and therapy offered in order to develop improved and customized counseling for them. Methods. We reviewed the intake forms of the American women who called the NVP Helpline from 2008 to 2012. We extracted their state of residence, demographic data, severity of NVP symptoms, and other available clinical characteristics. Results. A total of 195 forms were reviewed. Of these, 86% called for information on management of NVP with/without questions about fetal drug safety, while 14% called solely about drug safety during pregnancy/breastfeeding. The majority of women were Caucasian, in their thirties, educated, employed, married and in their second pregnancy. Of them 95% were suffering from moderate-to-severe condition with 13% having hyperemesis gravidarum. Conclusion. American women need more information on the management of NVP and on a variety of its aspects in addition to the safety and effectiveness of antiemetic medications. Their leading concern was the use of doxylamine and vitamin B6 combination for NVP treatment followed by the use of ondansetron.
背景。妊娠恶心和呕吐（NVP）是孕期最常见的病症，影响多达85%的准妈妈。在美国，尚无美国食品药品监督管理局（FDA）批准用于治疗NVP的药物。目的。确定导致美国女性联系母胎风险NVP帮助热线的主要担忧，并描述她们症状的严重程度以及所提供的治疗方法，以便为她们制定更好的个性化咨询服务。方法。我们查阅了2008年至2012年拨打NVP帮助热线的美国女性的 intake 表格。我们提取了她们的居住州、人口统计学数据、NVP症状的严重程度以及其他可用的临床特征。结果。共查阅了195份表格。其中，86%的人询问了NVP的管理信息，有无关于胎儿药物安全性的问题，而14%的人仅询问了孕期/哺乳期的药物安全性。大多数女性是白人，三十多岁，受过教育，有工作，已婚，且是第二次怀孕。其中95%患有中度至重度病症，13%患有妊娠剧吐。结论。美国女性除了需要了解止吐药物的安全性和有效性外，还需要更多关于NVP管理及其各个方面的信息。她们最主要的担忧是使用多西拉敏和维生素B6联合治疗NVP，其次是使用昂丹司琼。
