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鼠伤寒沙门氏菌血清型 Typhi 具有非典型喹诺酮耐药表型。

Salmonella enterica Serotype Typhi with nonclassical quinolone resistance phenotype.

机构信息

Institut Pasteur, Paris, France.

出版信息

Emerg Infect Dis. 2011 Jun;17(6):1091-4. doi: 10.3201/eid/1706.101242.

DOI:10.3201/eid/1706.101242
PMID:21749778
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC3358197/
Abstract

We report Salmonella enterica serotype Typhi strains with a nonclassical quinolone resistance phenotype (i.e., decreased susceptibility to ciprofloxacin but with susceptibility to nalidixic acid) associated with a nonsynonymous mutation at codon 464 of the gyrB gene. These strains, not detected by the nalidixic acid disk screening test, can result in fluoroquinolone treatment failure.

摘要

我们报告了一些伤寒沙门氏菌血清型 Typhi 菌株，它们具有非典型的喹诺酮类药物耐药表型（即对环丙沙星的敏感性降低，但对萘啶酸的敏感性不变），与 gyrB 基因 464 密码子的非同义突变有关。这些菌株不能被萘啶酸纸片筛选试验检测到，但可能导致氟喹诺酮类药物治疗失败。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c074/3358197/dc4b06bf657e/10-1242-F2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c074/3358197/cda19bed1030/10-1242-F1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c074/3358197/dc4b06bf657e/10-1242-F2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c074/3358197/cda19bed1030/10-1242-F1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c074/3358197/dc4b06bf657e/10-1242-F2.jpg

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