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电针镇痛与阿片类药物在犬模型中的疗效比较:一项初步研究。

Effectiveness of electroacupuncture analgesia compared with opioid administration in a dog model: a pilot study.

机构信息

Department of Veterinary Clinical Science, Università degli Studi di Milano, Italy.

出版信息

Br J Anaesth. 2011 Oct;107(4):612-8. doi: 10.1093/bja/aer199. Epub 2011 Jul 12.

Abstract

BACKGROUND

Although opioid analgesics are the usual drugs to treat post-surgical pain, acupuncture has also been demonstrated to relieve various pain syndromes. The present pilot study aims to investigate the efficacy of electroacupuncture compared with a conventional opioid compound, butorphanol, for postoperative pain treatment in dogs undergoing elective ovariohysterectomy.

METHODS

Twelve dogs were randomly allocated into two groups. Dogs received either electroacupuncture stimulation (16 and 43 Hz) at Shen Shu, Chang Shu, He Gu, Tai Yuan, Zu San Li, Yang Ling Quan, and Bai Hui acupoints, while control dogs were treated with butorphanol. Cardiovascular and respiratory parameters were recorded for both groups during operation. Plasma β-endorphin concentrations were evaluated before surgery (baseline) and up to 24 h later. For each dog, pain was measured according to a dedicated subjective pain scoring system.

RESULTS

Plasma β-endorphin levels in dogs receiving electroacupuncture increased significantly against baseline values after 1 and 3 h after surgery. Moreover, the end-tidal isoflurane concentration needed for second ovary traction was significantly lower in acupuncture-treated dogs than control animals. All animals having electroacupuncture experienced prolonged analgesia, over 24 h at least, while four out of six dogs treated with butorphanol needed post-surgical ketorolac and tramadol supplementation to their pain relief.

CONCLUSIONS

The results obtained from the present investigation showed some evidence for electroacupuncture as an alternative technique to provide postoperative analgesia in dogs.

摘要

背景

尽管阿片类镇痛药通常是治疗术后疼痛的药物,但针灸也已被证明可缓解各种疼痛综合征。本初步研究旨在调查电针对接受择期卵巢子宫切除术的犬术后疼痛治疗的疗效,与常规阿片类复合药物丁丙诺啡相比。

方法

12 只狗随机分为两组。狗接受电针刺激(16 和 43 Hz)在肾俞、长舒、合谷、太渊、足三里、阳陵泉和百会穴位,而对照组狗则接受丁丙诺啡治疗。记录两组手术期间的心血管和呼吸参数。评估手术前(基线)和 24 小时后血浆β-内啡肽浓度。根据专门的主观疼痛评分系统,对每只狗进行疼痛测量。

结果

接受电针治疗的狗的血浆β-内啡肽水平在手术后 1 和 3 小时后与基线值相比显著增加。此外,接受电针治疗的狗在第二卵巢牵引时需要的异氟醚呼气末浓度明显低于对照组动物。所有接受电针治疗的动物均经历了至少 24 小时的延长镇痛,而 6 只接受丁丙诺啡治疗的狗中有 4 只需要术后给予酮咯酸和曲马多来补充其镇痛。

结论

本研究结果表明,电针作为一种替代技术,为犬提供术后镇痛提供了一些证据。

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