Servicio de Aparato Digestivo, Hospital Universitario La Princesa, Instituto de Investigación Sanitaria Princesa, Madrid, Spain.
J Clin Gastroenterol. 2011 Aug;45(7):630-7. doi: 10.1097/MCG.0b013e31820d3533.
Angiogenic factors are involved in the physiopathology of several inflammatory diseases and they probably play a role in the pathogenesis of acute pancreatitis (AP).
To investigate if angiogenic factors are elevated in patients with AP, their relationship with severity and clinical evolution of AP, and their use as prognosis markers of AP.
A case (25)-control (30) study was carried out. Patients with AP were classified according to severity (using Ranson and Glasgow scores) and according to their clinical evolution (taking into account the development of complications during hospital stay). Platelet-derived growth factor (PDGFBB), angiopoietin-1, angiopoietin-2 (Ang-2), angiopoietin tyrosine-kinase receptor, hepatocyte growth factor (HGF), vascular endothelial growth factor (VEGF), VEGF tyrosine-kinase receptor 1, and VEGF tyrosine-kinase receptor 2 were determined at 12 hours and then at 5 days after hospitalization.
PDGFBB, Ang-2, angiopoietin tyrosine-kinase receptor, and HGF were significantly higher in cases (P<0.001), and in patients with unfavorable clinical evolution (P<0.001). PDGFBB and HGF were significantly higher in patients with severe AP (P<0.05). To predict unfavorable clinical evolution, PDGFBB, Ang-2, and HGF showed an area under receiver operating characteristic curve of 0.97.
PDGFBB and HGF are related to severity of AP. These factors along with Ang-2 are related to clinical evolution and are useful in predicting the development of several complications during hospital stay. Therefore, these angiogenic factors could be useful as prognosis markers of AP.
血管生成因子参与多种炎症性疾病的病理生理过程，它们可能在急性胰腺炎（AP）的发病机制中起作用。
研究血管生成因子是否在 AP 患者中升高，及其与 AP 的严重程度和临床转归的关系，以及它们作为 AP 预后标志物的用途。
进行了病例（25 例）-对照（30 例）研究。根据严重程度（使用 Ranson 和 Glasgow 评分）和临床转归（考虑住院期间并发症的发展）对 AP 患者进行分类。在入院后 12 小时和第 5 天测定血小板衍生生长因子 BB（PDGFBB）、血管生成素-1、血管生成素-2（Ang-2）、血管生成素酪氨酸激酶受体、肝细胞生长因子（HGF）、血管内皮生长因子（VEGF）、VEGF 酪氨酸激酶受体 1 和 VEGF 酪氨酸激酶受体 2。
病例组 PDGFBB、Ang-2、血管生成素酪氨酸激酶受体和 HGF 明显升高（P<0.001），且临床转归不良的患者升高更明显（P<0.001）。PDGFBB 和 HGF 在重症 AP 患者中明显升高（P<0.05）。为预测不良临床转归，PDGFBB、Ang-2 和 HGF 的受试者工作特征曲线下面积为 0.97。
PDGFBB 和 HGF 与 AP 的严重程度有关。这些因子与 Ang-2 一起与临床转归有关，有助于预测住院期间发生多种并发症。因此，这些血管生成因子可作为 AP 的预后标志物。
