School of Chemistry and Environmental Science, Key Laboratory of Green Chemical Media and Reactions, Ministry of Education, Henan Normal University, Xinxiang, Henan 453007, People's Republic of China.
Phys Chem Chem Phys. 2011 Aug 28;13(32):14542-9. doi: 10.1039/c1cp20948e. Epub 2011 Jul 12.
Extensive applications of ionic liquids (ILs) may result in their accumulation in the ecological environment and organisms. Although ILs are popularly called "green solvents", their toxicity, in fact, has been exhibited. Therefore the interaction of ILs with biomolecules is a cutting-edge research subject. Herein, the interactions of 1-butyl-3-methylimidazolium carboxylate ionic liquids ([C(4)mim][HCOO], [C(4)mim][CH(3)COO] and [C(4)mim][CH(3)CH(2)COO]) with glucose in water were studied for their volumetric properties, viscosity, conductivity and NMR spectra. Limiting apparent molar volumes (V(Φ, IL)(0)), viscosity B-coefficients, limiting molar conductivities (Λ(0)) and Walden products (Λ(0)η(0)) were evaluated for the ILs in glucose + water solutions. Volumetric interaction parameters were also obtained from the transfer volumes of the ionic liquids. The contributions of the solvent properties (B(1)) and the ionic liquid-solvent interactions (B(2)) to the B-coefficient were extracted, together with molar activation energies (Δμ(IL)(0≠)) of the ionic liquids for viscous flow of the aqueous glucose + IL solution. In addition, the (13)C and (1)H NMR spectra of methyl β-D-glucopyranoside and ILs in β-D-glucopyranoside + IL + D(2)O were studied. The NMR results show that no special and strong interactions were observed between glucopyranoside and the ILs. However, it was confirmed that the H2 on the imidazolium ring has more activity (acidity) than atoms H4 and H5. The macro-properties and their changes were also discussed in terms of the size, structure and solvation of the ILs and glucose.
离子液体（ILs）的广泛应用可能导致其在生态环境和生物体内积累。尽管 ILs 通常被称为“绿色溶剂”，但实际上它们具有毒性。因此，ILs 与生物分子的相互作用是一个前沿的研究课题。在此，研究了 1-丁基-3-甲基咪唑羧酸离子液体([C(4)mim][HCOO]、[C(4)mim][CH(3)COO]和[C(4)mim][CH(3)CH(2)COO])与水中葡萄糖的相互作用，研究了其体积性质、粘度、电导率和 NMR 谱。评估了 IL 在葡萄糖+水溶液中的极限表观摩尔体积(V(Φ, IL)(0))、粘度 B 系数、极限摩尔电导率(Λ(0))和 Walden 乘积(Λ(0)η(0))。还从离子液体的转移体积中获得了体积相互作用参数。从溶剂性质(B(1))和离子液体-溶剂相互作用(B(2))对 B 系数的贡献中提取了离子液体的摩尔活化能(Δμ(IL)(0≠))，用于粘性流动的水溶液葡萄糖+IL 溶液。此外，还研究了甲基-β-D-吡喃葡萄糖苷和 ILs 在β-D-吡喃葡萄糖苷+IL+D(2)O 中的(13)C 和(1)H NMR 谱。NMR 结果表明，吡喃葡萄糖苷与 ILs 之间没有观察到特殊的强相互作用。然而，证实了咪唑环上的 H2 比原子 H4 和 H5 具有更高的活性（酸度）。还根据 ILs 和葡萄糖的大小、结构和溶剂化作用讨论了宏观性质及其变化。
