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硫代硒取代葡萄糖苷酶抑制剂中硫原子对肠道α-葡萄糖苷酶活性的影响。

The effect of heteroatom substitution of sulfur for selenium in glucosidase inhibitors on intestinal α-glucosidase activities.

机构信息

Department of Chemistry, Simon Fraser University, Burnaby, British Colombia, Canada V5A 1S6.

出版信息

Chem Commun (Camb). 2011 Aug 28;47(32):9134-6. doi: 10.1039/c1cc13052h. Epub 2011 Jul 13.

DOI:10.1039/c1cc13052h
PMID:21750824
Abstract

The synthesis of selenium analogues of de-O-sulfonated ponkoranol, a naturally occurring sulfonium-ion glucosidase inhibitor isolated from Salacia reticulata, and their evaluation as glucosidase inhibitors against two recombinant intestinal enzymes maltase glucoamylase (MGAM) and sucrase isomaltase (SI) are described.

摘要

本文描述了从 Salacia reticulata 中分离得到的天然存在的硫鎓离子葡萄糖苷酶抑制剂去-O-磺基波考那醇的硒类似物的合成及其作为两种重组肠酶麦芽糖淀粉酶 (MGAM) 和蔗糖异麦芽糖酶 (SI) 的葡萄糖苷酶抑制剂的评价。

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