University of South Carolina, Department of Chemistry and Biochemistry and Nanocenter, Columbia, SC 29208, USA.
Org Biomol Chem. 2011 Sep 21;9(18):6189-95. doi: 10.1039/c1ob05700f. Epub 2011 Jul 13.
In recent years, protein-based nanoparticles or bionanoparticles (BNPs), have been used as primary building blocks to generate ornate nanomaterials for a wide-range of applications. Over the past fifty years, numerous BNPs have been chemically modified or genetically engineered to function as smart drug/gene delivery vehicles, advanced vaccine vehicles, and isolated reaction vessels for inorganic, metallic, and semi-conductive depositions. These studies have contributed invaluable insights to the expansive capabilities of these simple, yet highly robust, nanosized building materials. Here we highlight some of the recent progress in the chemical modifications of BNPs and hopefully inspire the development of many new materials in the near future.
近年来，蛋白质纳米粒子或生物纳米粒子（BNPs）已被用作主要构建块，以生成用于广泛应用的华丽纳米材料。在过去的五十年中，已经对许多 BNPs 进行了化学修饰或基因工程改造，使其作为智能药物/基因传递载体、先进的疫苗载体以及无机、金属和半导体制备的隔离反应容器。这些研究为这些简单而又高度稳定的纳米级建筑材料的广泛应用提供了宝贵的见解。在这里，我们重点介绍 BNPs 的化学修饰的最新进展，并希望在不久的将来激发许多新材料的发展。
