Dubenko E G, Pishel' Ia V, Dubenko O E, Prikhod'ko A P
Zh Nevropatol Psikhiatr Im S S Korsakova. 1990;90(7):47-50.
As many as 115 patients with initial atherosclerotic discirculatory encephalopathy manifested alterations in the system of prostanoids towards vasoconstrictors and proaggregating agents, consequent on both reduction in the plasma of the metabolite prostacyclin and increase of the metabolite thromboxane. The alterations were found to be attended by activation of lipid peroxidation and deterioration of the cerebral and central hemodynamics. The treatment with the calcium antagonists verapamil and nifedipine favoured an increase in the content of prostacyclin and reduction of the content of TxB2. That was associated with improvement of the hemodynamic parameters. It may be assumed that the vasodilatory effect of the calcium antagonists is related to stimulation of the synthesis of prostacyclin . Besides, nifedipine treatment brought about a decrease in the blood plasma of lipid peroxidation products, which may be an additional factor of prostacyclin synthesis activation.
多达115例初始患有动脉粥样硬化性血液循环障碍性脑病的患者表现出前列腺素系统向血管收缩剂和促聚集剂的改变，这是由于代谢产物前列环素的血浆水平降低以及代谢产物血栓素增加所致。发现这些改变伴随着脂质过氧化的激活以及脑和中枢血流动力学的恶化。使用钙拮抗剂维拉帕米和硝苯地平进行治疗有利于前列环素含量的增加和血栓素B2含量的降低。这与血流动力学参数的改善相关。可以假定钙拮抗剂的血管舒张作用与前列环素合成的刺激有关。此外，硝苯地平治疗使脂质过氧化产物的血浆水平降低，这可能是前列环素合成激活的另一个因素。
