Akopov S E, Grigorian G S, Kazarian A V, Mkhitarian G S, Tunian Iu S, Gabrielian E S
Zh Nevropatol Psikhiatr Im S S Korsakova. 1991;91(7):63-6.
It is shown that in patients with cerebral circulatory disorders, the prostacyclin -thromboxane balance is replaced toward the latter one. As a result of nifedipine administration part of the test subjects demonstrate a rise of the content of prostacyclin and a decline of the concentration of thromboxane. This effect of nifedipine is ascertained to be in a good agreement with its action on blood inflow to the brain and platelet aggregation. It is concluded that the efficacy of nifedipine can be raised if it is combined with the drugs that enhance the synthesis of prostacyclins in the body.
结果表明，在脑循环障碍患者中，前列环素-血栓素平衡向血栓素方向转变。给予硝苯地平后，部分受试者前列环素含量升高，血栓素浓度降低。硝苯地平的这种作用与其对脑血流量和血小板聚集的作用高度一致。得出结论，如果将硝苯地平与能增强体内前列环素合成的药物联合使用，其疗效可能会提高。
