Cardiovascular Division, Department of Medicine, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA 02215, USA.
Curr Cardiol Rep. 2011 Oct;13(5):432-8. doi: 10.1007/s11886-011-0197-y.
Prior to the widespread adoption of intracoronary stent implantation, potential complications of percutaneous coronary intervention (PCI) necessitated the presence of backup cardiac surgery. However, as stent implantation has become the predominant form of PCI, the incidence of emergent cardiac surgery has declined exponentially. Despite this, current guidelines recommend against the performance of elective PCI at hospitals without on-site cardiac surgery and recommend that primary PCI for ST-segment elevation myocardial infarction (STEMI) might be considered at hospitals without backup cardiac surgery. These recommendations are based predominantly on two principles: (1) hospital volume for PCI is strongly associated with clinical outcomes, and (2) results from a large registry study, in which the authors reported a substantial increase in mortality among patients undergoing non-primary/rescue PCI at hospitals without backup cardiac surgery. Since that time, evidence from multiple studies has suggested that performance of PCI at hospitals without backup cardiac surgery is feasible, safe, and both clinically and cost effective. Among STEMI patients, in particular, performance of primary PCI at hospitals without on-site cardiac surgery reduces time to reperfusion and subsequent adverse cardiovascular events as well as likely reducing infarct size. In this review, we will examine the evidence surrounding the performance of PCI for stable and unstable coronary disease at hospitals without on-site backup cardiac surgery.
在冠状动脉支架植入术广泛应用之前,经皮冠状动脉介入治疗(PCI)的潜在并发症需要心脏外科手术作为后备。然而,随着支架植入术成为 PCI 的主要形式,紧急心脏手术的发生率呈指数级下降。尽管如此,目前的指南仍建议不在有心脏外科手术的医院进行选择性 PCI,并建议在没有后备心脏手术的医院考虑进行 ST 段抬高型心肌梗死(STEMI)的直接 PCI。这些建议主要基于两个原则:(1)PCI 的医院量与临床结果密切相关,(2)一项大型注册研究的结果,作者报告在没有后备心脏手术的医院进行非直接/抢救性 PCI 的患者死亡率显著增加。自那时以来,多项研究的证据表明,在没有后备心脏手术的医院进行 PCI 是可行的、安全的,并且在临床和成本效益方面都是有效的。特别是在 STEMI 患者中,在没有现场心脏外科手术的医院进行直接 PCI 可缩短再灌注时间和随后的不良心血管事件发生时间,并可能减少梗死面积。在这篇综述中,我们将研究在没有现场后备心脏手术的医院进行稳定和不稳定型冠心病 PCI 的相关证据。