Qin L J, Wen J, Qu Y L, Huang Q Y
College of Life Sciences, Central China Normal University, Wuhan, China.
Genet Mol Res. 2013 Sep 3;12(3):3324-34. doi: 10.4238/2013.September.3.9.
Uncoupling protein 2 (UCP2) is a mitochondrial transporter protein and can affect the function of β-cells. We investigated a possible association between functional UCP2 -866G/A and Ala55Val polymorphisms and type 2 diabetes in 715 Hubei Han Chinese. No significant association was found, either for the -866G/A polymorphism (allele, P = 0.254; genotype, P = 0.508) or for the Ala55Val polymorphism (allele, P = 0.250; genotype, P = 0.896). Then, we reviewed the association of UCP2 -866G/A and Ala55Val polymorphisms with type 2 diabetes susceptibility in the Chinese population with a meta-analysis. Our meta-analysis, which included 3643 Chinese, further confirmed a lack of association of -866G/A and Ala55Val with type 2 diabetes (additive model: -866G/A, odds ratio = 1.09, 95% confidence interval = 0.94-1.27, P = 0.25; Ala55Val, odds ratio = 1.21, 95% confidence interval = 0.85-1.72, P = 0.28). Based on our case-control study and meta-analysis, we conclude that UCP2 Ala55Val and -866G/A polymorphisms are not significantly associated with type 2 diabetes risk in the Chinese population.
解偶联蛋白2（UCP2）是一种线粒体转运蛋白，可影响β细胞的功能。我们在715名湖北汉族人中研究了功能性UCP2 -866G/A和Ala55Val多态性与2型糖尿病之间的可能关联。未发现-866G/A多态性（等位基因，P = 0.254；基因型，P = 0.508）或Ala55Val多态性（等位基因，P = 0.250；基因型，P = 0.896）存在显著关联。然后，我们通过荟萃分析回顾了UCP2 -866G/A和Ala55Val多态性与中国人群2型糖尿病易感性的关联。我们纳入3643名中国人的荟萃分析进一步证实-866G/A和Ala55Val与2型糖尿病缺乏关联（相加模型：-866G/A，比值比 = 1.09，95%置信区间 = 0.94 - 1.27，P = 0.25；Ala55Val，比值比 = 1.21，95%置信区间 = 0.85 - 1.72，P = 0.28）。基于我们的病例对照研究和荟萃分析，我们得出结论：在中国人群中，UCP2 Ala55Val和-866G/A多态性与2型糖尿病风险无显著关联。
