自主神经功能障碍症状在运动症状出现一年内区分帕金森病（PD）与多系统萎缩（MSA-P）中的作用。
Role of dysautonomic symptoms in distinguishing Parkinson's disease (PD) from multiple system atrophy (MSA-P) within a year of developing motor symptoms.
作者信息
Ragothaman Mona, Swaminath Pazhayannur V, Sarangmath Nagaraja, Koshy Suma, Adhyam Mohan, Subbakrishna Dodaballapur K, Mathias Christopher J, Muthane Uday B
机构信息
Department of Neurology, National Institute of Mental Health and Neurosciences, Bangalore 560029, India.
出版信息
J Assoc Physicians India. 2011 Feb;59:95-8.
OBJECTIVE
Can dysautonomic symptoms occurring within a year of developing motor symptoms distinguish Multiple system atrophy-Parkinsonian (MSA-P) from Parkinson's disease (PD)?
PATIENTS AND METHODS
Seventy-two Parkinsonian patients diagnosed as probable PD or MSA-P.
RESULTS
PD (n = 58, 80.6%) and MSA (n = 14, 19.4%) patients were of similar age and had motor symptoms for similar duration. PD first presents with motor symptoms (68.3%) while MSA-P presents with dysautonomia (85.7%). Urinary incontinence was reported by MSA-P (64%) at their first visit and was absent in most PD (98%) patients.
CONCLUSIONS
Urinary incontinence and orthostatic symptoms occurring in a parkinsonian patient within one-year history of motor symptoms suggests a diagnosis of MSA-P with high accuracy and their absence suggests PD.
目的
运动症状出现后一年内出现的自主神经功能障碍症状能否区分帕金森型多系统萎缩（MSA-P）和帕金森病（PD）？
患者与方法
72例被诊断为可能的PD或MSA-P的帕金森病患者。
结果
PD患者（n = 58，80.6%）和MSA患者（n = 14，19.4%）年龄相似，运动症状持续时间相似。PD首次出现运动症状（68.3%），而MSA-P首次出现自主神经功能障碍（85.7%）。MSA-P患者首次就诊时报告有尿失禁（64%），而大多数PD患者（98%）无尿失禁。
结论
帕金森病患者在运动症状出现一年内出现尿失禁和体位性症状提示高度准确的MSA-P诊断，而无这些症状提示PD。
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