Surathi Pratibha, Jhunjhunwala Ketan, Yadav Ravi, Pal Pramod Kumar
Department of Neurology, National Institute of Mental Health and Neurosciences, Hosur Road, Bangalore, Karnataka, India.
Ann Indian Acad Neurol. 2016 Jan-Mar;19(1):9-20. doi: 10.4103/0972-2327.167713.
Parkinson's disease (PD) is a common neurodegenerative disorder affecting patients in large numbers throughout the world. In this article, we review all the published data on PD based on studies in Indian population. We have tried to consolidate the contribution of Indian studies in PD research. We found 95 articles, of which 92 were original research papers. This is a relatively less number, but in the last decade, there has been an increase in research on PD from this country. But most of them seem to be restricted to only a few research institutes. The nonmotor symptoms and genetics are the most commonly studied aspects. The systematic review of the articles reveals that the epidemiology in India may be different with relatively lesser incidence here. Most of the genetic mutations found to cause PD in other population are not found in India, revealing that other genetic factors may be involved. Further research needs to be encouraged to understand the disease in Indian patients better, as all the results cannot be extrapolated from the Western literature to this heterogeneous Indian population. There need to be more studies on therapeutic aspects of the disease.
帕金森病（PD）是一种常见的神经退行性疾病，在全球范围内影响着大量患者。在本文中，我们基于对印度人群的研究，回顾了所有已发表的关于帕金森病的数据。我们试图整合印度研究在帕金森病研究中的贡献。我们找到了95篇文章，其中92篇是原创研究论文。这个数量相对较少，但在过去十年中，该国对帕金森病的研究有所增加。但其中大多数研究似乎仅局限于少数几个研究机构。非运动症状和遗传学是最常研究的方面。对这些文章的系统综述表明，印度的流行病学情况可能有所不同，这里的发病率相对较低。在其他人群中发现的大多数导致帕金森病的基因突变在印度并未发现，这表明可能涉及其他遗传因素。需要鼓励进一步开展研究，以便更好地了解印度患者的病情，因为不能将所有结果从西方文献外推到这个异质性的印度人群。还需要对该疾病的治疗方面进行更多研究。
