Department of Endocrinology and Metabolism, Goztepe Education and Research Hospital, Istanbul, Turkey.
Thyroid. 2011 Aug;21(8):891-6. doi: 10.1089/thy.2009.0200. Epub 2011 Jul 13.
Vitamin D insufficiency, defined as serum levels of 25-hydroxyvitamin D [25(OH)D3] lower than 30 ng/mL, has been reported to be prevalent in several autoimmune diseases such as multiple sclerosis and type 1 diabetes mellitus. The goal of the present study was to assess whether vitamin D insufficiency is also a feature of Hashimoto's thyroiditis (HT).
We performed a prevalence case-control study that included 161 cases with HT and 162 healthy controls. Serum levels of 25(OH)D3, calcium, phosphorus, and parathyroid hormone were measured in all 323 subjects.
The prevalence of vitamin D insufficiency in HT cases (148 of 161, 92%) was significantly higher than that observed in healthy controls (102 of 162, 63%, p < 0.0001). Among HT cases, the prevalence rate of vitamin D insufficiency showed a trend to be higher in patients with overt hypothyroidism (47 of 50, 94%) or subclinical hypothyroidism (44 of 45, 98%) than in those with euthyroidism (57 of 66, 86%), but the differences were not significant (p = 0.083).
Vitamin D insufficiency is associated with HT. Further studies are needed to determine whether vitamin D insufficiency is a casual factor in the pathogenesis of HT or rather a consequence of the disease.
维生素 D 不足（定义为血清 25-羟维生素 D [25(OH)D3]水平低于 30ng/mL）已在多种自身免疫性疾病中报道，如多发性硬化症和 1 型糖尿病。本研究的目的是评估维生素 D 不足是否也是桥本甲状腺炎（HT）的特征。
我们进行了一项病例对照研究，包括 161 例 HT 患者和 162 例健康对照者。所有 323 名受试者均检测血清 25(OH)D3、钙、磷和甲状旁腺激素水平。
HT 患者（161 例中的 148 例，92%）维生素 D 不足的患病率明显高于健康对照组（162 例中的 102 例，63%，p<0.0001）。在 HT 患者中，显性甲状腺功能减退症（50 例中的 47 例，94%）或亚临床甲状腺功能减退症（45 例中的 44 例，98%）患者维生素 D 不足的患病率呈上升趋势，但差异无统计学意义（p=0.083）。
维生素 D 不足与 HT 相关。需要进一步研究以确定维生素 D 不足是 HT 发病机制中的一个偶然因素，还是疾病的结果。
