儿童和青少年维生素D缺乏与桥本甲状腺炎：这种关联存在临界维生素D水平吗？
Vitamin D Deficiency and Hashimoto's Thyroiditis in Children and Adolescents: a Critical Vitamin D Level for This Association?
作者信息
Evliyaoğlu Olcay, Acar Manolya, Özcabı Bahar, Erginöz Ethem, Bucak Feride, Ercan Oya, Kucur Mine
机构信息
İstanbul University Cerrahpaşa Faculty of Medicine, Department of Pediatric Endocrinology, İstanbul, Turkey Phone: +90 533 633 15 64 E-mail:
出版信息
J Clin Res Pediatr Endocrinol. 2015 Jun;7(2):128-33. doi: 10.4274/jcrpe.2011.
OBJECTIVE
Vitamin D has been suggested to be active as an immunomodulator in autoimmune diseases such as Hashimoto's thyroiditis (HT). The goal of the present study was to investigate the vitamin D status in HT patients.
METHODS
This prevalence case-control study was conducted on 90 patients with HT (of ages 12.32 ± 2.87 years) and 79 age-matched healthy controls (11.85 ± 2.28 years). Serum 25-hydroxyvitamin D3 [25(OH)D3] levels were measured in all 169 subjects.
RESULTS
The prevalence of vitamin D deficiency in HT patients (64 of 90; 71.1%) was significantly higher than that in the control group (41 of 79; 51.9%) (p=0.025). Mean serum 25(OH)D3 level in the HT group was significantly lower compared to the control group (16.67 ± 11.65 vs. 20.99 ± 9.86 ng/mL, p=0.001). HT was observed 2.28 times more frequently in individuals with 25(OH)D3 levels <20 ng/mL (OR: 2.28, CI: 1.21-4.3).
CONCLUSION
Vitamin D deficiency is associated with HT in children and adolescents. Levels lower than 20 ng/mL seem to be critical. The mechanism for this association is not clear.
目的
维生素D被认为在自身免疫性疾病如桥本甲状腺炎（HT）中作为一种免疫调节剂发挥作用。本研究的目的是调查HT患者的维生素D状态。
方法
本患病率病例对照研究对90例HT患者（年龄12.32±2.87岁）和79例年龄匹配的健康对照者（11.85±2.28岁）进行。对所有169名受试者测量血清25-羟基维生素D3[25(OH)D3]水平。
结果
HT患者中维生素D缺乏的患病率（90例中的64例；71.1%）显著高于对照组（79例中的41例；51.9%）（p=0.025）。HT组的血清25(OH)D3平均水平显著低于对照组（16.67±11.65对20.99±9.86 ng/mL，p=0.001）。25(OH)D3水平<20 ng/mL的个体中HT的发生率高2.28倍（比值比：2.28，可信区间：1.21 - 4.3）。
结论
维生素D缺乏与儿童和青少年的HT有关。低于20 ng/mL的水平似乎至关重要。这种关联的机制尚不清楚。
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