Evliyaoğlu Olcay, Acar Manolya, Özcabı Bahar, Erginöz Ethem, Bucak Feride, Ercan Oya, Kucur Mine
İstanbul University Cerrahpaşa Faculty of Medicine, Department of Pediatric Endocrinology, İstanbul, Turkey Phone: +90 533 633 15 64 E-mail:
J Clin Res Pediatr Endocrinol. 2015 Jun;7(2):128-33. doi: 10.4274/jcrpe.2011.
Vitamin D has been suggested to be active as an immunomodulator in autoimmune diseases such as Hashimoto's thyroiditis (HT). The goal of the present study was to investigate the vitamin D status in HT patients.
This prevalence case-control study was conducted on 90 patients with HT (of ages 12.32 ± 2.87 years) and 79 age-matched healthy controls (11.85 ± 2.28 years). Serum 25-hydroxyvitamin D3 [25(OH)D3] levels were measured in all 169 subjects.
The prevalence of vitamin D deficiency in HT patients (64 of 90; 71.1%) was significantly higher than that in the control group (41 of 79; 51.9%) (p=0.025). Mean serum 25(OH)D3 level in the HT group was significantly lower compared to the control group (16.67 ± 11.65 vs. 20.99 ± 9.86 ng/mL, p=0.001). HT was observed 2.28 times more frequently in individuals with 25(OH)D3 levels <20 ng/mL (OR: 2.28, CI: 1.21-4.3).
Vitamin D deficiency is associated with HT in children and adolescents. Levels lower than 20 ng/mL seem to be critical. The mechanism for this association is not clear.
维生素D被认为在自身免疫性疾病如桥本甲状腺炎（HT）中作为一种免疫调节剂发挥作用。本研究的目的是调查HT患者的维生素D状态。
本患病率病例对照研究对90例HT患者（年龄12.32±2.87岁）和79例年龄匹配的健康对照者（11.85±2.28岁）进行。对所有169名受试者测量血清25-羟基维生素D3[25(OH)D3]水平。
HT患者中维生素D缺乏的患病率（90例中的64例；71.1%）显著高于对照组（79例中的41例；51.9%）（p=0.025）。HT组的血清25(OH)D3平均水平显著低于对照组（16.67±11.65对20.99±9.86 ng/mL，p=0.001）。25(OH)D3水平<20 ng/mL的个体中HT的发生率高2.28倍（比值比：2.28，可信区间：1.21 - 4.3）。
维生素D缺乏与儿童和青少年的HT有关。低于20 ng/mL的水平似乎至关重要。这种关联的机制尚不清楚。
