桥本甲状腺炎患儿的维生素D状况。
Vitamin D status in children with Hashimoto thyroiditis.
作者信息
Camurdan Orhun M, Döğer Esra, Bideci Aysun, Celik Nurullah, Cinaz Peyami
机构信息
Department of Pediatric Endocrinology, School of Medicine, Gazi University, Ankara, Turkey.
出版信息
J Pediatr Endocrinol Metab. 2012;25(5-6):467-70.
OBJECTIVE
To investigate vitamin D status in children with Hashimoto thyroiditis.
SUBJECTS AND METHODS
The study group consisted of 78 children recently diagnosed as Hashimoto thyroiditis and 74 subjects as the control group. Parameters of calcium metabolism, thyroid function tests, and 25-hydroxyvitamin D [25(OH)D] levels were measured.
RESULTS
Vitamin D deficiency rate was significantly higher in the Hashimoto group compared with the control subjects (73.1% vs. 17.6%, p < 0.0001). In the Hashimoto group, mean 25(OH)D levels were significantly lower compared with the control group (31.2 +/- 11.5 versus 57.9 +/- 19.7 nmol/L, p < 0.001) and was inversely correlated with the anti-thyroid peroxidase (anti-TPO) levels (r = -0.30, p = 0.007).
CONCLUSION
The higher vitamin D deficiency rates besides lower vitamin D levels in the Hashimoto group together with the inverse correlation between vitamin D and anti-TPO suggest that vitamin D deficiency may have a role in the autoimmune process in Hashimoto thyroiditis in children.
目的
研究桥本甲状腺炎患儿的维生素D状况。
对象与方法
研究组由78例近期诊断为桥本甲状腺炎的儿童组成，对照组有74例受试者。检测钙代谢参数、甲状腺功能指标及25-羟维生素D[25(OH)D]水平。
结果
桥本组维生素D缺乏率显著高于对照组（73.1%对17.6%，p<0.0001）。桥本组平均25(OH)D水平显著低于对照组（31.2±11.5对57.9±19.7 nmol/L，p<0.001），且与抗甲状腺过氧化物酶（抗-TPO）水平呈负相关（r = -0.30，p = 0.007）。
结论
桥本组维生素D缺乏率较高且维生素D水平较低，同时维生素D与抗-TPO呈负相关，提示维生素D缺乏可能在儿童桥本甲状腺炎的自身免疫过程中起作用。
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