Division of Endocrinology and Metabolism, Department of Internal Medicine, College of Medicine, Korea University, Seoul 152-050, Republic of Korea; Department of Internal Medicine, Cardiovascular and Metabolic Disease Center, Inje University, Busan, Republic of Korea.
Department of Statistics, College of Natural Sciences, Sungshin Women's University, Seoul, Republic of Korea.
Diabetes Res Clin Pract. 2011 Aug;93(2):285-291. doi: 10.1016/j.diabres.2011.06.013. Epub 2011 Jul 14.
Sarcopenia measured as appendicular skeletal muscle mass (ASM), and central obesity measured as visceral fat area (VFA) may act synergistically to influence metabolic syndrome and atherosclerosis. However, several previous studies reported that metabolic risk is higher in non-sarcopenic obesity groups than in sarcopenic obesity groups because of the close relationship between muscle mass and body fat. We investigated the association of the ASM to VFA ratio, which we have termed the muscle-to-fat ratio (MFR), with metabolic syndrome and arterial stiffness.
This study was performed in 526 apparently healthy adults enrolled in the Korean Sarcopenic Obesity Study, an ongoing prospective observational cohort study. ASM was evaluated with dual energy X-ray absorptiometry and VFA with computed tomography. Arterial stiffness was measured using brachial-ankle pulse wave velocity (baPWV).
MFR was significantly associated with waist circumference, blood pressure, lipid profiles, glucose and baPWV. By multiple logistic regression analysis, the odds ratio for metabolic syndrome was 5.43 (lowest versus highest tertile of MFR, 95% confidence interval, 2.56-13.34). Multiple stepwise regression analysis showed that MFR was an independent determinant of baPWV (R²=0.57).
MFR, a new index of sarcopenic obesity, showed an independent negative association with metabolic syndrome and arterial stiffness.
四肢骨骼肌质量（ASM）和内脏脂肪面积（VFA）等衡量的肌肉减少症和中心性肥胖可能协同作用，影响代谢综合征和动脉粥样硬化。然而，一些先前的研究报告称，非肌肉减少性肥胖组的代谢风险高于肌肉减少性肥胖组，因为肌肉质量与体脂肪密切相关。我们研究了肌肉与脂肪比值（MFR）与代谢综合征和动脉僵硬的相关性。
这项研究在韩国肌肉减少性肥胖研究中进行，这是一项正在进行的前瞻性观察性队列研究，共纳入 526 名貌似健康的成年人。使用双能 X 射线吸收仪评估 ASM，使用计算机断层扫描评估 VFA。使用肱踝脉搏波速度（baPWV）测量动脉僵硬程度。
MFR 与腰围、血压、血脂谱、血糖和 baPWV 显著相关。通过多因素逻辑回归分析，代谢综合征的优势比为 5.43（最低与最高三分位 MFR，95%置信区间，2.56-13.34）。逐步多元回归分析显示，MFR 是 baPWV 的独立决定因素（R²=0.57）。
作为肌肉减少性肥胖的新指标，MFR 与代谢综合征和动脉僵硬呈独立负相关。
