Wright K C, Loh G, Wallace S, Stephens L C
Division of Diagnostic Imaging, University of Texas, M.D. Anderson Cancer Center, Houston 77030.
Cardiovasc Intervent Radiol. 1990 Oct-Nov;13(5):309-13. doi: 10.1007/BF02578633.
Adult mongrel dogs were used to evaluate and compare the use of ethanol and ethanol-Ethiodol for transcatheter renal arterial embolization. Each agent was administered into a main renal artery in five dogs and evaluated with regard to ease of use, radiopacity, arterial occlusion, parenchymal damage, and toxicity. Both agents were easy to inject, and no complications were encountered in any of the animals. Ethiodol added the ability to fluoroscopically monitor the infusate for reflux and distribution, yielded a more homogeneous distribution of the ethanol within the renal vasculature, and increased the embolic effects of the ethanol. Adding Ethiodol to ethanol should decrease the latter's complications since administration can be monitored fluoroscopically and a smaller volume of ethanol could perhaps be used to achieve the desired result. Additional research is needed to determine the safety of administering larger volumes of Ethiodol into the renal artery.
成年杂种犬被用于评估和比较乙醇及乙醇-碘油在经导管肾动脉栓塞术中的应用。每种药剂分别注入5只犬的一条主要肾动脉，并就易用性、造影性、动脉闭塞、实质损伤及毒性进行评估。两种药剂均易于注射，且所有动物均未出现并发症。碘油增强了在荧光镜下监测注入物反流及分布的能力，使乙醇在肾血管系统内分布更均匀，并增强了乙醇的栓塞效果。向乙醇中添加碘油应可减少乙醇的并发症，因为可通过荧光镜监测给药过程，或许使用较少量的乙醇就能达到预期效果。需要进一步研究以确定向肾动脉内注入更大剂量碘油的安全性。
