Backlund Brianna, Zoran Debra L, Nabity Mary B, Norby Bo, Bauer John E
Department of Small Animal Clinical Sciences, Texas A&M College of Veterinary Medicine and Biomedical Sciences, College Station, TX, USA.
J Feline Med Surg. 2011 Oct;13(10):698-704. doi: 10.1016/j.jfms.2011.05.019. Epub 2011 Jul 14.
This study evaluates the effect of dietary protein content on renal parameters in 23 healthy spayed female cats. The objective was to determine if cats eating diets high in protein will have higher serum urea nitrogen (UN) and creatinine values without a detectable change in kidney function, as assessed by urinalysis. A single random cross-over design was used. Cats were fed a standard maintenance diet for at least 1 month prior to the dietary trial. They were fed in two phases. For the first phase, cats were randomly assigned to receive either a high protein [HP=46% metabolizable energy (ME)] or low protein (LP=26% ME) diet. For the second phase, cats were fed whichever diet they were not fed during the phase I period. Blood and urine samples were collected at 2-week intervals for the duration of the study (10 weeks). UN, albumin, alanine aminotransferase and urine specific gravity were significantly higher, and creatinine and phosphorus were significantly lower (P<0.05) when cats were fed the HP diet as compared to when they were fed the LP diet, although none of the mean values were found to be outside of the corresponding reference interval. Dietary intake can result in clinically significant changes in UN and statistically significantly changes in several other biochemical analytes, although all analytes are likely to remain within normal reference intervals. Therefore, an accurate dietary history is necessary to help determine if renal parameters are being influenced by diet in a particular patient.
本研究评估了饮食蛋白质含量对23只健康绝育雌性猫肾脏参数的影响。目的是确定食用高蛋白饮食的猫是否会有更高的血清尿素氮（UN）和肌酐值，而通过尿液分析评估的肾功能无明显变化。采用单一随机交叉设计。在饮食试验前，猫被喂食标准维持饮食至少1个月。它们分两个阶段喂食。在第一阶段，猫被随机分配接受高蛋白[HP = 46%可代谢能量（ME）]或低蛋白（LP = 26% ME）饮食。在第二阶段，猫被喂食它们在第一阶段未食用的饮食。在研究期间（10周），每隔2周采集血液和尿液样本。与喂食LP饮食相比，猫喂食HP饮食时，UN、白蛋白、丙氨酸转氨酶和尿比重显著更高，肌酐和磷显著更低（P<0.05），尽管所有平均值均未超出相应的参考区间。饮食摄入可导致UN出现临床显著变化，并使其他几种生化分析物出现统计学显著变化，尽管所有分析物可能仍保持在正常参考区间内。因此，准确的饮食史对于帮助确定特定患者的肾脏参数是否受到饮食影响是必要的。
