Dipartimento di Medicina del Lavoro Clinica del Lavoro L. Devoto, Sezione di Statistica Medica e Biometria G.A.Maccacaro, Università degli Studi di Milano, Italy.
J Cyst Fibros. 2011 Sep;10(5):370-6. doi: 10.1016/j.jcf.2011.06.004. Epub 2011 Jul 12.
Influenza, like other respiratory viral infections, can cause acute deterioration of lung function in patients with cystic fibrosis (CF). Previous studies on a small number of patients reported that most people with CF infected with A (H1N1) influenza experienced a mild course of disease.
To characterise the impact of A (H1N1) infection on CF in a large number of patients from different centres and countries.
CF centres accessing the web-site of the European Cystic Fibrosis Society (ECFS) were asked to report clinical data on patients with an ascertained diagnosis of influenza caused by the A (H1N1) virus. The study was web-based and data were collected through an electronic data sheet on the ECFS website.
Twenty-five centres from 10 countries caring for 4698 patients with CF reported data on 110 patients (2.3%), median age 13 years (range 1-39 years). The prevalence of infection in each centre ranged from 0% to 9.4%. Only 8.8% of the patients had been vaccinated. The main symptoms were fever and respiratory exacerbation requiring IV antibiotics in 53% of the patients; 48% of the patients were hospitalised for an average of 12.9 days (range 2-56) and 31% required oxygen treatment during the time of the infection. Most of the patients recovered and FEV(1) 1 month after the infection was similar to that before the infection. However, 6 patients were admitted to ICU, 5 with mechanical ventilation. Three patients with severe respiratory disease died.
A (H1N1) influenza infection caused transient but significant morbidity in most of the patients with CF. However, in a small number of patients with severe lung disease, A (H1N1) influenza was associated with respiratory deterioration, mechanical ventilation and even death.
流感与其他呼吸道病毒感染一样，可导致囊性纤维化（CF）患者的肺部功能急性恶化。先前对少数患者的研究报告称，大多数感染 A（H1N1）流感的 CF 患者疾病进程较轻。
在来自不同中心和国家的大量患者中，描述 A（H1N1）感染对 CF 的影响。
访问欧洲囊性纤维化学会（ECFS）网站的 CF 中心被要求报告经确诊的由 A（H1N1）病毒引起的流感患者的临床数据。该研究为网络研究，通过 ECFS 网站上的电子数据表收集数据。
来自 10 个国家的 25 个 CF 中心报告了 110 例（2.3%）患者的数据，中位年龄为 13 岁（范围 1-39 岁）。各中心的感染发生率从 0%至 9.4%不等。仅有 8.8%的患者接种了疫苗。主要症状为发热和需静脉使用抗生素治疗的呼吸恶化，占 53%；53%的患者住院，平均住院时间为 12.9 天（范围 2-56 天），31%的患者在感染期间需要吸氧治疗。大多数患者康复，感染后 1 个月的 FEV1与感染前相似。然而，6 例患者被收入 ICU，其中 5 例使用了机械通气。3 例严重呼吸系统疾病患者死亡。
A（H1N1）流感感染使大多数 CF 患者出现短暂但显著的发病率。然而，在少数患有严重肺部疾病的患者中，A（H1N1）流感与呼吸恶化、机械通气甚至死亡相关。
