Department of Health Sciences and the EMGO Institute for Health and Care Research, Faculty of Earth and Life Sciences, VU University, Amsterdam, The Netherlands.
J Nutr. 2011 Sep;141(9):1673-8. doi: 10.3945/jn.110.134668. Epub 2011 Jul 13.
Consumption of industrial trans fatty acids (iTFA) increases LDL cholesterol, decreases HDL cholesterol, and is strongly associated with a higher risk of cardiovascular disease (CVD). However, changes in circulating cholesterol cannot explain the entire effect. Therefore, we studied whether iTFA and conjugated linoleic acid (CLA) affect markers of inflammation and oxidative stress. Sixty-one healthy adults consumed each of 3 diets for 3 wk, in random order. Diets were identical except for 7% of energy provided by oleic acid (control diet), iTFA, or CLA. At the end of the 3 wk, we measured plasma inflammatory markers IL-6, C-reactive protein, tumor necrosis factor receptors I and II (TNF-RI and -RII), monocyte chemotactic protein-1 and E-selectin, and urinary 8-iso-PGF(2α), a marker of lipid peroxidation. Consumption of iTFA caused 4% lower TNF-RI concentrations and 6% higher E-selectin concentrations compared with oleic acid (control) and had no significant effect on other inflammatory markers. CLA did not significantly affect inflammatory markers. The urine concentration of 8-iso-PGF(2α) [geometric mean (95% CI)] was greater after the iTFA [0.54 (0.48, 0.60) nmol/mmol creatinine] and the CLA [1.2 (1.1, 1.3) nmol/mmol creatinine] diet periods than after the control period [0.45 (0.41, 0.50) nmol/mmol creatinine; P < 0.05]. In conclusion, high intakes of iTFA and CLA did not substantially affect plasma concentrations of inflammatory markers, but they increased the urine 8-iso-PGF(2α) concentration. However, it is unlikely this plays a major role in the mechanism by which iTFA increase the risk of CVD. However, more research is needed to fully understand the implications of these findings.
工业反式脂肪酸（iTFA）的摄入会增加 LDL 胆固醇，降低 HDL 胆固醇，并且与心血管疾病（CVD）的风险增加密切相关。然而，循环胆固醇的变化并不能解释全部影响。因此，我们研究了 iTFA 和共轭亚油酸（CLA）是否会影响炎症和氧化应激标志物。61 名健康成年人以随机顺序连续 3 周食用 3 种饮食中的每一种。除了 7%的能量来自油酸（对照饮食）、iTFA 或 CLA 外，饮食完全相同。在 3 周结束时，我们测量了血浆炎症标志物 IL-6、C 反应蛋白、肿瘤坏死因子受体 I 和 II（TNF-RI 和 -RII）、单核细胞趋化蛋白-1 和 E-选择素以及尿液 8-异前列腺素 F2α（8-iso-PGF(2α)），这是脂质过氧化的标志物。与油酸（对照）相比，iTFA 的 TNF-RI 浓度降低了 4%，E-选择素浓度升高了 6%，而对其他炎症标志物没有显著影响。CLA 对炎症标志物没有显著影响。iTFA[0.54（0.48，0.60）nmol/mmol 肌酐]和 CLA[1.2（1.1，1.3）nmol/mmol 肌酐]饮食期尿液 8-iso-PGF(2α)浓度[几何均数（95%CI）]均高于对照期[0.45（0.41，0.50）nmol/mmol 肌酐；P < 0.05]。总之，iTFA 和 CLA 的高摄入量并未显著影响血浆炎症标志物浓度，但增加了尿液 8-iso-PGF(2α)浓度。然而，这不太可能在 iTFA 增加 CVD 风险的机制中起主要作用。然而，需要进一步研究以充分了解这些发现的意义。
