Intra-renal interactions between angiotensin II and atrial natriuretic factor.

ANF and Ang II have opposing functions in volume homeostasis. The extent to which they interact functionally in the glomerulus, tubules and vasculature of the kidney is examined. Functional antagonism occurs in the glomerulus due to actions on different components; ANF appears to act mainly on capillary permeability and Ang II on vasculature and capillary surface area. A major cellular interaction is apparent in the proximal tubule where inhibition of sodium transport by ANF appears to be Ang II-dependent. No interaction is evident in the distal nephron, but an opposing functional action on medullary vasculature has been demonstrated.