Olusi S O
Department of Chemical Pathology, Faculty of Health Sciences, Obafemi Awolowo University, Ile-Ife, Nigeria.
Trop Geogr Med. 1990 Jan;42(1):41-6.
Using isoelectric focusing in polyacrylamide gel, alpha-1-antitrypsin phenotyping was carried out in 1,000 normal Nigerians and in 25 with hepatocellular carcinoma, 17 with cirrhosis of the liver and 193 with neonatal jaundice. The percentage frequency of the homozygous alpha-1-antitrypsin deficiency state (PiZZ) in the normal, healthy population was 0.2% compared with 4% in those with hepatoma, 5.9% in those with liver cirrhosis and 0.5% in those with neonatal jaundice. These findings suggest that alpha-1-antitrypsin deficiency may be a contributory factor in the pathogenesis of hepatocellular carcinoma and cirrhosis of the liver in Nigeria.
采用聚丙烯酰胺凝胶等电聚焦法，对1000名正常尼日利亚人以及25例肝细胞癌患者、17例肝硬化患者和193例新生儿黄疸患者进行了α-1抗胰蛋白酶表型分析。正常健康人群中纯合子α-1抗胰蛋白酶缺乏状态（PiZZ）的百分比频率为0.2%，而肝癌患者中为4%，肝硬化患者中为5.9%，新生儿黄疸患者中为0.5%。这些发现表明，α-1抗胰蛋白酶缺乏可能是尼日利亚肝细胞癌和肝硬化发病机制中的一个促成因素。
