Theodoropoulos G, Fertakis A, Archimandritis A, Kapordelis C, Angelopoulos B
Acta Hepatogastroenterol (Stuttg). 1976 Apr;23(2):114-7.
The phenotypic distribution of alpha-1-antitrypsin variants has been studied in 101 patients with cirrhosis and in 50 with cirrhosis plus hepatoma. 504 healthy Greeks served as controls. The ZZ and MZ phenotypes were found only once in the group of cirrhosis. The very low PiZ gene frequency suggests that the association of PiZ gene with cirrhosis is fortuitous. The FM phenotype has been observed in 14% of patients with hepatoma arised on cirrhosis and this incidence differed significantly between the two groups of patients and the controls. It is possible that cirrhotic patients phenotypically FM develop for as yet unknown reasons hepatoma in high percentage.
对101例肝硬化患者和50例肝硬化合并肝癌患者的α1-抗胰蛋白酶变体的表型分布进行了研究。504名健康希腊人作为对照。在肝硬化组中仅发现一次ZZ和MZ表型。极低的PiZ基因频率表明PiZ基因与肝硬化的关联是偶然的。在肝硬化基础上发生肝癌的患者中，14%观察到FM表型，该发生率在两组患者和对照组之间存在显著差异。有可能表型为FM的肝硬化患者由于尚未明确的原因而有很高比例发生肝癌。
