Smanadhikorn P, Pongpaew P, Srivatanakul P, Tungtrongchitr R, Supanaranond W, Schelp F P, Migasena P
Department of Tropical Nutritional and Food Science, Faculty of Tropical medicine, Mahidol University, Bangkok, Thailand.
Southeast Asian J Trop Med Public Health. 1995 Jun;26(2):240-2.
The risk of developing liver cirrhosis, hepatoma (HCC) and bile duct carcinoma (BDC) have been associated with homozygous alpha 1-antitrypsin (AT) deficiency especially linked to the Z allele. While the association between liver cancers and AT deficiency remains debatable, the risk of adult AT deficiency carriers to develop liver cirrhosis has not been assessed quantitatively. Liver cancers and liver diseases with subsequent liver cirrhosis are highly prevalent in tropical countries such as Thailand and heterozygous AT phenotypes are rather common in this country as well. The aim of this study was to assess the risk of developing liver cirrhosis, HCC and BDC by means of case-control studies with Thai patients and controls in connection with AT deficiency. For hepatitis, HCC and BDC to association with AT deficiency was detected. Carriers of PiMZ phenotype in Thailand have a high risk to develop liver cirrhosis (odds. ratio of 10.8, 95% confidence interval = 1.3-88.1). Patients with predisposing diseases should be screened for Pi phenotypes so that rigorous measures to combat the occurrence of liver cirrhosis can be implemented.
肝硬化、肝癌（HCC）和胆管癌（BDC）的发生风险与纯合子α1-抗胰蛋白酶（AT）缺乏有关，尤其是与Z等位基因相关。虽然肝癌与AT缺乏之间的关联仍存在争议，但成人AT缺乏携带者发生肝硬化的风险尚未进行定量评估。在泰国等热带国家，肝癌和随后发展为肝硬化的肝脏疾病非常普遍，杂合子AT表型在该国也相当常见。本研究的目的是通过对泰国患者和对照进行病例对照研究，评估与AT缺乏相关的肝硬化、HCC和BDC的发生风险。对于肝炎、HCC和BDC与AT缺乏的关联进行了检测。泰国PiMZ表型的携带者发生肝硬化的风险很高（优势比为10.8，95%置信区间=1.3-88.1）。对有易感疾病的患者应进行Pi表型筛查，以便实施严格措施来对抗肝硬化的发生。
