瞬时受体电位经典通道在血管生成和轴突导向中的作用。
Transient receptor potential canonical channels in angiogenesis and axon guidance.
机构信息
State Key Laboratory of Neuroscience, Institute of Neuroscience, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences.
出版信息
Cell Mol Life Sci. 2011 Dec;68(23):3815-21. doi: 10.1007/s00018-011-0755-x. Epub 2011 Jul 14.
Abstract
Wiring of vascular and neural networks requires precise guidance of growing blood vessels and axons, respectively, to reach their targets during development. Both of the processes share common molecular signaling pathways. Transient receptor potential canonical (TRPC) channels are calcium-permeable cation channels and gated via receptor- or store-operated mechanisms. Recent studies have revealed the requirement of TRPC channels in mediating guidance cue-induced calcium influx and their essential roles in regulating axon navigation and angiogenesis. Dissecting TRPC functions in these physiological processes may provide therapeutic implications for suppressing pathological angiogenesis and improving nerve regeneration.
摘要
血管和神经网络的布线分别需要精确引导生长的血管和轴突，以使其在发育过程中到达各自的靶标。这两个过程都共享共同的分子信号通路。瞬时受体电位经典型 (TRPC) 通道是钙通透性阳离子通道，通过受体或储存操作机制进行门控。最近的研究揭示了 TRPC 通道在介导导向信号诱导的钙内流中的作用及其在调节轴突导航和血管生成中的重要作用。剖析 TRPC 在这些生理过程中的功能可能为抑制病理性血管生成和改善神经再生提供治疗意义。
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