Li Ka Shing Institute of Health Sciences and School of Biomedical Sciences, The Chinese University of Hong Kong, Hong Kong, China.
Adv Exp Med Biol. 2011;704:759-80. doi: 10.1007/978-94-007-0265-3_40.
Endothelial cells regulate multiple vascular functions, such as vascular tone, permeability, remodeling, and angiogenesis. It is known for long that cytosolic Ca(2+) level (Ca(2+)) and membrane potential of endothelial cells are crucial factors to initiate the signal transduction cascades, leading to diverse vascular functions. Among the various kinds of endothelial ion channels that regulate ion homeostasis, transient receptor potential (TRP) channels emerge as the prime mediators for a diverse range of vascular signaling. The characteristics of TRP channels, including subunit heteromultimerization, diverse ion selectivity, and multiple modes of activation, permit their versatile functional roles in vasculatures. Substantial amount of evidence demonstrates that many TRP channels in endothelial cells participate in physiological and pathophysiological processes of vascular system. In this article, we summarize the recent findings of TRP research in endothelial cells, aiming at providing up-to-date information to the researchers in this rapidly growing field.
内皮细胞调节多种血管功能，如血管张力、通透性、重塑和血管生成。长期以来，人们已经知道细胞浆钙离子水平([Ca^(2+)]_(i))和内皮细胞的膜电位是启动信号转导级联反应的关键因素，从而导致多种血管功能。在调节离子稳态的各种内皮离子通道中，瞬时受体电位 (TRP) 通道成为多种血管信号的主要介质。TRP 通道的特性，包括亚基异源多聚体化、多样化的离子选择性和多种激活模式，使其在脉管系统中具有多种功能作用。大量证据表明，内皮细胞中的许多 TRP 通道参与了血管系统的生理和病理生理过程。本文总结了内皮细胞中 TRP 研究的最新发现，旨在为该快速发展领域的研究人员提供最新信息。
