Pende A, Musso N R, Vergassola C, Puppo F, Ioverno A, Criscuolo D, Indiveri F, Lotti G
Medical Pathology R and Clinical Methodology, ISMI, University of Genova, Italy.
J Biol Regul Homeost Agents. 1990 Apr-Jun;4(2):67-72.
The acute effects of interferon alpha-2a (3 x 10 IU im) on catecholamine and immunoreactive beta endorphin plasma levels, cortisol serum levels and lymphocyte beta 2-adrenoceptor density were evaluated in ten healthy volunteers. Interferon induced a significant increase in plasma norepinephrine; there was an increased norepinephrine standing response, too. On the contrary, epinephrine standing response was reduced by interferon. Lymphocyte beta 2-adrenoceptors decreased significantly after interferon administration; dissociation constant of binding was unchanged. Cortisol serum levels increased significantly with respect to control test, whereas immunoreactive beta endorphin did not change. These results support the hypothesis of functional relationships between neuroendocrine and immune systems; moreover they may be useful in clinical trials given the administration of interferon alpha in an increasing number of diseases.
在10名健康志愿者中评估了干扰素α-2a（3×10 IU，肌肉注射）对儿茶酚胺、免疫反应性β内啡肽血浆水平、皮质醇血清水平和淋巴细胞β2-肾上腺素能受体密度的急性影响。干扰素使血浆去甲肾上腺素显著增加；去甲肾上腺素的站立反应也增强。相反，干扰素使肾上腺素的站立反应减弱。给予干扰素后淋巴细胞β2-肾上腺素能受体显著减少；结合解离常数未变。与对照试验相比，皮质醇血清水平显著升高，而免疫反应性β内啡肽没有变化。这些结果支持神经内分泌系统和免疫系统之间存在功能关系的假说；此外，鉴于越来越多的疾病使用干扰素α进行治疗，这些结果可能对临床试验有用。
