Garcia-Godoy Franklin, Murray Peter
Department of Bioscience Research, College of Dentistry, University of Tennessee Health Science Center, Memphis, TN, USA.
J Tenn Dent Assoc. 2010 Fall;90(4):12-8; quiz 18-9.
Scientific advances in the creation of restorative biomaterials, in vitro cell culture technology, tissue engineering, molecular biology and the human genome project provide the basis for the introduction of new technologies into dentistry. This review provides an assessment of how tissue engineering, stem cell, genetic transfer, biomaterial and growth factor therapies can be integrated into clinical dental therapies to restore and regenerate oral tissues. In parallel to the creation of a new field in general medicine called "regenerative medicine," we call this field "regenerative dentistry." While the problems of introducing regenerative therapies are substantial, the potential benefits to patients and the profession are equally ground-breaking. In this review, we outline a few areas of interest for the future of oral and dental medicine in which advancements in basic science have already been adapted to fit the goals of 21st century dentistry.
修复性生物材料的研发、体外细胞培养技术、组织工程、分子生物学以及人类基因组计划等方面的科学进展，为将新技术引入牙科奠定了基础。本综述评估了组织工程、干细胞、基因转移、生物材料和生长因子疗法如何整合到临床牙科治疗中，以修复和再生口腔组织。与在普通医学中创建一个名为“再生医学”的新领域并行，我们将这个领域称为“再生牙科”。虽然引入再生疗法存在诸多问题，但对患者和该行业的潜在益处同样具有开创性。在本综述中，我们概述了口腔医学未来几个令人感兴趣的领域，其中基础科学的进展已被应用于契合21世纪牙科的目标。
