Kirkpatrick C James, Fuchs Sabine, Peters Kirsten, Brochhausen Christoph, Hermanns M Iris, Unger Ronald E
Laboratory for REgenerative PAthology & Interface Research (REPAIR-lab), Institute of Pathology, Johannes Gutenberg University Mainz, Germany.
Artif Organs. 2006 Oct;30(10):822-7. doi: 10.1111/j.1525-1594.2006.00306.x.
This article gives a brief overview of the authors' views on the future development of tissue engineering with respect to the challenges both to the materials and life sciences. Emphasis will be placed on the advantages of three-dimensional bioresorbable polymers in combination with relevant molecular cues and the application of autologous stem or progenitor cells. There is a requirement for much more diversity in the synthesis of so-called "intelligent" materials, which respond to external stimuli, as well as the development of novel drug and gene delivery systems. In addition, much more basic research is necessary in developmental biology and the application of modern cell and molecular biology to biomaterial questions.
本文简要概述了作者对于组织工程未来发展的观点，涉及材料科学和生命科学所面临的挑战。重点将放在三维可生物降解聚合物与相关分子信号相结合的优势以及自体干细胞或祖细胞的应用上。在合成对外部刺激有反应的所谓“智能”材料方面，以及在开发新型药物和基因递送系统方面，都需要更多样化。此外，在发育生物学以及将现代细胞和分子生物学应用于生物材料问题方面，还需要更多的基础研究。
