Krzesinski J M, Christiaens L, Palem-Vliers M, Fenghe D, Pequeux-Bar M L, Lomba-Pignon M R, Genard P, Rorive G
Service de néphrologie, CHU Sart-Tilman, Belgique.
Arch Mal Coeur Vaiss. 1990 Jul;83(8):1229-31.
In order to explain the opposite effect of 6,7-dihydroxylated isomers of 6, 7 - dihydrocanrenone on the urinary sodium and potassium excretion, we have tested the effect of these substances isolated from human urine on the Na(+)-K+ pump from different tissue preparation: rabbit kidney slices as well as NA-K ATPase purified from the kidney. Our results show an inhibition of pump as well as enzyme activity by the 6 beta 7 alpha isomer while the 2 other isomers are either uneffective or slightly stimulating. The 6 beta 7 alpha dihydroxy-6, 7-dihydrocanrenone could be one of the plasma ouabain-like substance incriminated in the pathogenesis of volume-expanded hypertension.
为了解释6,7 - 二氢坎利酮的6,7 - 二羟基化异构体对尿钠和钾排泄的相反作用，我们测试了从人尿中分离出的这些物质对不同组织制剂中钠钾泵的作用：兔肾切片以及从肾脏中纯化的钠钾ATP酶。我们的结果显示，6β7α异构体对泵以及酶活性有抑制作用，而其他两种异构体要么无效，要么有轻微刺激作用。6β7α - 二羟基 - 6,7 - 二氢坎利酮可能是与容量扩张性高血压发病机制有关的血浆哇巴因样物质之一。
