恶性淋巴瘤患者中爱泼斯坦-巴尔病毒（EBV）特异性体液免疫和细胞免疫的不一致性：抗体滴度升高和体外淋巴细胞反应性降低。
Discordance of Epstein-Barr Virus (EBV) specific humoral and cellular immunity in patients with malignant lymphomas: elevated antibody titres and lowered in vitro lymphocyte reactivity.
作者信息
Ten Napel C H, The T H, Van Egten-Bijker J, de Gast G C, Halie M R, Langenhuysen M M
出版信息
Clin Exp Immunol. 1978 Dec;34(3):338-46.
The relationship between specific viral cellular and humoral immunity to the Epstein–Barr Virus (EBV) was investigated in thirty-one untreated patients with malignant lymphoma (ML) and sex- and age-matched controls. reactivity of peripheral blood lymphocytes to heatinactivated purified EBV, in an optimal stimulating concentration, was measured with H-thymidine uptake. In seropositive individuals EBV lymphocyte reactivity was positively related to EBV virus capsid antibody titres. In contrast, ML patients, especially those with Hodgkin's disease, showed markedly (<0·01) impaired EBV lymphocyte reactivity in association with raised EBV virus capsid antibody titres. The disturbance of EBV lymphocyte reactivity was not related to the impairment of non-specific lymphocyte reactivity to mitogens and recall antigens in these patients. This study supports the hypothesis that depressed cellular immunity may cause raised EBV antibodies in ML, especially in Hodgkin's disease.
在31例未经治疗的恶性淋巴瘤（ML）患者以及性别和年龄匹配的对照组中，研究了针对爱泼斯坦 - 巴尔病毒（EBV）的特异性病毒细胞免疫和体液免疫之间的关系。采用³H - 胸腺嘧啶核苷摄取法，测定外周血淋巴细胞在最佳刺激浓度下对热灭活纯化EBV的反应性。在血清阳性个体中，EBV淋巴细胞反应性与EBV病毒衣壳抗体滴度呈正相关。相比之下，ML患者，尤其是霍奇金病患者，EBV淋巴细胞反应性明显受损（<0.01），同时EBV病毒衣壳抗体滴度升高。这些患者中EBV淋巴细胞反应性的紊乱与对有丝分裂原和回忆抗原的非特异性淋巴细胞反应性受损无关。本研究支持这样的假说，即细胞免疫抑制可能导致ML患者，尤其是霍奇金病患者的EBV抗体升高。
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