Department of Pharmacology & Toxicology, University of Veterinary and Animal Sciences, Lahore, Pakistan.
Eur J Pharmacol. 2011 Oct 1;668(1-2):6-14. doi: 10.1016/j.ejphar.2011.06.044. Epub 2011 Jul 7.
Artemisinins in combination with other antimalarial drugs remain the mainstay of current antimalarial armamentarium. It is interesting to note that many traditional drugs with antiprotozoal background can wield immunomodulation on the recipient's immune system in a positive or negative direction. Artemisinins also attribute immunomodulatory distensions. For instance, they demonstrate predominant immunosuppressive traits toward different immune components by particularly regulating the cellular proliferation and cytokine release, which indicates that they possess some additional mechanisms and features demanding deliberate attentions. This article reviews the data-based immunomodulatory effects of artemisinins on different immune cells including neutrophils, macrophages, splenocytes, T and B cells in conjunction with their therapeutic prospective with regard to inflammation, autoimmunity and delayed-type hypersensitivity.
青蒿素类药物联合其他抗疟药物仍然是当前抗疟药物的主要组成部分。有趣的是，许多具有抗原生动物背景的传统药物可以在正向或负向上对接受者的免疫系统产生免疫调节作用。青蒿素类药物也具有免疫调节作用。例如，它们通过特别调节细胞增殖和细胞因子释放，对不同的免疫成分表现出明显的免疫抑制特性，这表明它们具有一些需要注意的额外机制和特征。本文综述了青蒿素类药物对中性粒细胞、巨噬细胞、脾细胞、T 细胞和 B 细胞等不同免疫细胞的基于数据的免疫调节作用及其在炎症、自身免疫和迟发型超敏反应方面的治疗前景。
