Intercollege Graduate Degree Program in Neuroscience, The Pennsylvania State University, University Park, PA 16802, USA.
Pharmacol Biochem Behav. 2011 Oct;99(4):759-74. doi: 10.1016/j.pbb.2011.06.032. Epub 2011 Jul 5.
3,4-Methylenedioxymethamphetamine (MDMA, ecstasy) is one of the most widely abused illegal drugs. Some users self-report euphoria and an increased perception and feeling of closeness to others. When taken in warm environments, MDMA users may develop acute complications with potential fatal consequences. In rodents, MDMA increases locomotor activity and, depending on ambient temperature, may produce a dose-dependent, potentially lethal hyperthermia. Like most other recreational drugs, MDMA is frequently taken in combination with other substances including tobacco, EtOH, marijuana, amphetamines, cocaine and, caffeine. Although polydrug use is very common, the understanding of the effects of this multiple substance use, as well as the analysis of consequences of different drug-drug associations, received rather little attention. The purpose of this review is to summarize our current knowledge about the changes on MDMA-related behavior, pharmacology, and neurotoxicity associated with co-consumption of other drugs of abuse and psychoactive agents.
3,4-亚甲二氧基甲基苯丙胺（MDMA，摇头丸）是最广泛滥用的非法药物之一。一些使用者自我报告欣快感和对他人的感知和感觉增加。当在温暖的环境中服用时，MDMA 用户可能会出现急性并发症，并有潜在的致命后果。在啮齿动物中，MDMA 会增加运动活动，并且根据环境温度，可能会产生剂量依赖性的、潜在致命的体温过高。像大多数其他娱乐性药物一样，MDMA 经常与其他物质一起服用，包括烟草、乙醇、大麻、安非他命、可卡因和咖啡因。尽管多药滥用非常普遍，但对这种多种物质使用的影响的理解，以及对不同药物 - 药物相互作用后果的分析，并没有得到太多关注。本综述的目的是总结我们目前对与 MDMA 相关的行为、药理学和神经毒性相关的变化的认识，这些变化与其他滥用药物和精神活性药物的共同消费有关。
